WVSOM -- Physiology Endocrine Diseases
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each of the black spaces below before clicking
on it to display the answer.
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| Growth Hormone Excess (pre-puberty) | gigantism
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| Growth Hormone Excess (post-puberty) | acromegally, increased organ size, glucose intolerance
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| Prolactin deficiency | Failure to lacate
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| Factors that increase prolactin secretion | estrogen, breast-feeding, sleep, stress, TRH, dopamine antagonists
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| Factors that decrease prolactin secretion | deopamine, bromocriptine, somatostatin, prolactin
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| Hyperthyroidism symptoms | increased metabolic rate, weight loss, negative Nitrogen balance, incrased heat production, increased cardiac output, dyspnea, tremor, weakness, goiter
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| Hyperthyroid causes | graves disease, thyroid neoplasm
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| Graves Disease | Antibodies to TSH receptor
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| TSH Levels in Hyperthyroidism | decreased
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| Addison’s Disease | autoimmune destruction of adrenal cortex; Primary adrenocortical insufficiency
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| Clinical features of Addison’s Disease | hypoglycemia, anorexia, weight loss, nausea, vomiting, weakness, hypotension, Hyperkalemia, metabolic acidosis, decresased pubic and axillary hair in women
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| Cushing’s Syndrome | adrenocortical excess; hyperplasia of adrenal glands….not to be confused with Cushing’s Disease
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| Clinical features of Cushing’s Syndrome | hyperglycemia, muscle wasting, central obesity, round face, buffalo hump, osteoporosis, striae, verilzation and menstrual disorders in women, HTN
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| ACTH levels in Cushing’s | decreased (negative feedback of cortisol)
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| Cushings Disease | overproduction of ACTH; usually drug induced; same symptoms as Cushing Syndrome
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| Conn’s Syndrome | aldosterone secreting tumor
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| Congenital Adrenal hyperplasia | deficiency in CYP21A2, CYP11B1, CYP 17, StAR
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| CYP 17 deficiancy | results in decreased cortisol production by slowing conversion of pregnelone and progesterone to the cortisol pathway
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| CYP11B1 deficiency | decreased aldosterone and cortisol production
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| CYP21A2 deficiency | decreased aldosterone and cortisol production
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| Hypothalmic Diabetes Insipidis | Deficiency in ADH
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| Nephrogenic Diabetes Insipidis | Renal resistance to ADH
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| Dipsogenic Diabetes Insipidis | Excessive Water drinking
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Created by:
tjamrose
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