WVSOM -- Cell Cycle control
Help!
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| What are the two kinds of cyclins? | G1 and G2
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| What is CDK | cyclic dependant kinase
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| Whant does CDK kinase activity increase? | When G1 and G2 levels are higher
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| What special name goes with the cdk G2 cyclins? | cdc2
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| What do the MPF complxes do? | phosphorylate nuclear lamins, H1 Histone, MAP kinase and cdc25
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| What is MPF | It is teh complex of the cdc2 and the G2 cyclin cofactors together
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| What does MPF allow between complexes? | cross talk
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| What are teh checkpoints? | Other pathways that control the pathway of the cdk pathway within thecycle
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| Restriction point | Middle of G1 and allows the cell to progress to S phase
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| Where is teh check point to check completion of DNA replication? | End of S
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| Tumor suppression genes | During S phase. Checks for damaged DNA;
If active it prevents the cell from progression.
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| Kinetochore-mitotic spindle associated checkpoint | During Mitosis and checks to make sure everythign is connected to the spindles
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| why are checkpoints important? | without them cancer occurs
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| Why do cancers occur? | checkpoints break down
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| Multi-kit hypothesis | One mutation cannot cause cancer
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| What are most common cancer mutaion? | in p53 and the blastoma (tumor suppressor gene)
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| Ungel genes | when over expressed cause cancer; will cause the cell to keep producing
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| How does retinoblastoma get phosphorylated to release E2F? | the GI cyclin/cdk complex phosphoyrlates the RB until it releases E2F
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| What is E2F? | a transcription factor that lead to S phase
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| DNA Damage ocogenes lead to what enzyme? | p53
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| Where can p53 lead to if correction is not made? | apoptosis
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| Where can p53 lead to? | apoptosis or p21
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Created by:
tjamrose