Comprehensive Pharm 2
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| MOA phenytoin | Increases Na channel inactivation
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| MOA carbamazepine | Increases Na channel inactivation
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| MOA lamotrigine | blocks voltage gated Na channels
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| MOA gabapentin | increases GABA release
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| MOA topiramate | Blocks Na channels, increases GABA release
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| MOA phenobarbital | increases GABA
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| MOA valproic acid | increases GABA, blocks Na channels
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| MOA ethosuxamide | blocks ca channels in thalamus
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| MOA benzos | increases GABA
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| uses for phenytoin | everything but absence seizures. status epilepticus prophylaxis
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| usees for lamotrigine | everything but status epilepticus
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| uses for carbamazepine | everything but absence and status
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| uses for gabapentin | all seizures except absence and status peripheral neuropathy
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| uses for topirimate | everything but absence and status
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| uses for phenobarbital | everything but absence and status
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| uses for valproic acid | everything but status
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| uses for ethosuxamide | absence
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| uses for benzos in epilepsy | acute status
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| which anti-epileptic drugs are 1st line in pregnancy and children | phenobarbital
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| which epi drug is 1st line for trigeminal neuralgia | carbamazepine
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| which drug is used to treat peripheral neuropathy | gabapentin
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| which drug is used to treat myoclonic seizures | valproic acid
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| which drug is used to treat seizures in eclampsia | MgSO4 (1st line) benzos
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| which epileptic drug --> sedation, tolerance, and dependence? | benzos
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| which epileptic drug --> aplastic anemia, liver toxicity, and teratogenesis? | carbamazepine
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| which epileptic drug --> diplopia, ataxia? | carbamazepine phenytoin
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| which epileptic drug --> GI distress, lethargy, headache? | ethosuxamide
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| which epileptic drugs --> stevens johnson syndrome | ethosuxamide lamotragine
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| which epileptic drug --> nystagmus, gingival hyperplasia, hirsutism? | phenytoin
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| which epileptic drug --> SLE like sydnrome | phenytoin
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| which epi drug --> spina bifida and other NTDs | valproic acid
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| which epi drug --> kidney stones | topiramate
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| which epilepsy drug --> malignant hyperthermia? | phenytoin
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| how do you treat OD of barbiturates? | symptom management
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| how do you treat OD of benzos? | flumazenil (competitive antagonist at GABA receptor)
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| other than for epilepsy, what can phenytoin be used for? | anti-arrhythmic
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| which is more dangerous in overdose: benzos or barbiturates? | barbiturates (longer t1/2 and more respiratory/cv depression)
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| MOA l-dopa | l dopa crosses bbb (dopamine doesn't) so it is converted to dopamine by dopa decarboxylase in CNS
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| carbidopa | peripheral decarboxylase inhibitor in order to increase bioavailability in brain and decrease peripheral side effects (since the conversion to dopamine won't occur peripherally)
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| toxicity of l-dopa? | arrhythmias from peripheral conversion of DA dyskinesia following lt admin akinesia between doses
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| MOA selegiline | selectively inhibits MAO-B, increasing availability of DA
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| use of selegiline | adjunctive to l-dopa in parkinsons
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| toxicityy of selegeliene | enhances l-dopa toxicity
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| MOA sumatriptan | 5-HT1D agonist --> vasoconstriction
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| use of sumatriptan | acute migraine cluster headache attacks
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| what type of drug is bethanechol? | direct cholinergic agonist
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| what type of drug is carbechol | direct cholinergic agonist
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| what type of drug is pilocarpine | direct cholinergic agonist
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| what type of drug is methacholine | direct cholinergic agonist
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| what is the difference between direct cholinergic agonsts and indirect? | direct directly stimulate cholinergic receptors and indirect inhibit their breakdown via AChE
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| uses of bethanechol | activates bladder and bowel smooth muscle (used post-op for ileus and urinary retention)
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| uses of carbechol | glaucoma pupillary contraction release of intraocular pressure
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| uses of pilocarpine | potent stimulator for saliva, sweat, and tears
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| uses of methacholine | challenge test for asthma dx
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| action of methacholine | stimulates muscarinic receptors in airway
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| class: neostigmine | indirect cholinomimetic
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| class pyrodostigmine | indirect cholinomimetic
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| class: edrophonium | indirect cholinomimetic
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| class: physostigmine | indirect cholinomimetic
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| class: echothiophate | indirect cholinomimetic
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| uses for neostigmine | post-op and neurogenic ileus and uriNAry retention MG reversal of NM junction blockade
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| uses for pyridostigmine | MG
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| uses for edrophonium | to dx MG
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| uses for physostigmine | glaucoma and atropine OD
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| uses for echothiophate | glaucoma
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| which indirect ACh agonist penetrates CNS | physostigmine
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