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MSK 2

Quiz yourself by thinking what should be in each of the black spaces below before clicking on it to display the answer.
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Question
Answer
Heberden's nodes (DIP) and Bouchard's nodes (PIP)   osteoarthritis  
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pain in weight-bearing joints after use that improves with rest   osteoarthritis  
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destruction of articular cartilage, subchondral bone formation, sclerosis, osteophytes, and eburnation are associated with what?   osteoarthritis  
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what are joint mice? what are they associated with?   osteophytes that fracture and float into synovial fluid along with fragments of separated cartilage - seen in osteoarthritis  
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pannus formation in joints, especially MCP, PIP   rheumatoid arthritis  
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morning stiffness improving with use; symmetric joint involvement, and systemic symptoms (fever, fatigue, pleuritis, pericarditis)   rheumatoid arthritis  
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Rx for severe cases of osteoporosis?   bisphosphonates or pulsatile PTH  
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type I osteoporosis?   postmenopausal - increased bone resorption due to decreased estrogen levels  
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type II osteoporosis?   senile osteoporosis - affects men and women over 70  
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what types of fractures are associated with type I osteoporosis?   vertebral crush fractures - acute back pain, loss of height, kyphosis  
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what type of fractures are associated with type II osteoporosis?   distal radius (Colles') fractures, vertebral wedge fractures  
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in this disease there is a failure of normal bone resorption that leads to thickened, dense bones   osteopetrosis (marble bone disease)  
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in this disease osteoclasts function abnormally   osteopetrosis  
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what level of alk phos is osteopetrosis associated with?   normal  
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what causes osteitis fibrosa cystica?   hyperparathyroidism  
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this disease is characterized by 'brown tumors', high serum calcium, low serum phosphorus, and high alk phos   osteitis fibrosa cystica  
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these are cystic spaces lined by osteoclasts, filled with fibrous stroma and sometimes blood   brown tumors (seen in osteitis fibrosa cystica)  
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in this disease there is abnormal bone architecture caused by an increase in both osteoblastic and osteoclastic activity   Paget's disease (osteitis deformans)  
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what level of alk phos is Paget's disease associated with?   increased (normal serum calcium, phosphorus, adn PTH)  
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in this disease, bone is replaced by fibroblasts, collagen, and irregular bony trabeculae   polyostotic fibrous dysplasia  
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Albright's syndrome is a form of what?   polyostotic fibrous dysplasia  
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multiple unilateral bone lesions, unilateral ppigmented skin lesions, precocious puberty   Albright's syndrome  
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pain and stiffness in shoulders and hips, often with fever, malaise and weight loss; doesn't cause muscular weakness   polymyalgia rheumatica  
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what is polymyalgia rheumatica associated with?   temporal (giant cell) arteritis; occurs in patients over 50  
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is ESR increased or decreased in polymyalgia rheumatica?   increased  
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progressive proximal muscle weakness caused by CD8+ T cell-induced injury to myofibers   polymyositis  
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muscle biopsy with evidence of inflammation is diagnostic for what?   polymyositis  
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increased CK, increased aldolase, and positive ANA, anti-Jo-1   polymyositis/dermatomyositis  
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Raynaud's, arthralgias, myalgias, fatigue, esophageal hypomotility   mixed CT disease  
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antibodies to U1RNP?   mixed connective tissue disease  
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what is the classic triad of Sjogren's syndrome?   xerophthalmia, xerostomia, arthritis  
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patients with Sjogren's syndrome are at increased risk for what?   B cell lymphoma  
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what is enlarged in Sjogren's syndrome?   parotids  
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what patients does Sjogren's primarily affect?   females between 40-60  
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autoantibodies to ribonucleoprotein antigens, SS-A (Ro), SS-B (La)   Sjogren's  
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fever, fatigue, weight loss, nonbacterial verrucous endocarditis, hilar adenopathy, and Raynaud's   SLE  
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what are the kidney findings in SLE?   wire loop lesions in kidney with immune complex deposition (with nephrotic syndrome)  
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what part of the SI does celiac sprue tend to affect?   jejunem  
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what skin finding is celiac sprue associated with?   dermatitis herpetiformis  
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what malignancy is celiac sprue most strongly affiliated with?   T cell lymphoma  
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blunting of villi and lymphocytes in the lamina propria are suggestive of what?   celiac sprue  
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