Psychiatric Pharmacology Flashcards
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What are the indications and contraindications for Lithium? | Indications: prophylaxis and treatment of mania, prophylaxis of bipolar affective disorder, treatment-resistant depression
Contraindications: dehydration, untreated hypothyroidism
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What is the mechanism of action of Lithium? | Widely distributed within the CNS and interacts with receptors to decrease noradrenaline release and increase serotonin synthesis
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What are the side effects of Lithium? | Fine tremor, renal impairment, thirst, weight gain Toxicity Long-term treatment can cause thyroid disorders and mild cognitive impairment
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What are the signs of toxicity of Lithium? | Toxicity signs usually appear at levels above 1.3mmol/l o Early signs: tremor, nausea and vomiting, metallic taste in mouth o Late signs: disorientation, dysarthria (slurred speech), convulsions, coma o Death from cardiac or pulmonary complications
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