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ch. 35: antihyperglycemic and hypoglycemic meds

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Question
Answer
first line med fore type II diabetes?   metformin. if unsuccessful, dose can be increased, or other drugs can be added.  
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criteria for diagnosis of DM?   faster serum greater than 126 OR random glucose >200 with symptoms OR a serum glucose of >200 2 hrs after 75g glucose given (OGGT) OR HbA1c>6.5%. any pos test must be confirmed with another test.  
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those that are approaching diabetes type 2 but still do not have the criteria for that diagnosis are said to have..   metabolic syndrome (pre-diabetes). fasting serum glucose in these people are 100-125 mg/dL  
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regular monitor for diabetes sugars after diagnosis should be done how often and with what test?   every six months with HbA1c, which should always be maintained below seven percent.  
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metformin goes under what category of drugs?   biguanide.  
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MOA of biguanide?   inhibit absorption of glucose from gut, decrease glucose output y liver, increase glucose uptake in adipose tissue and sk. muscle.  
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metformin sholuld be stopped when/   prior to administration of IV contrast agents and should not be re started for 48 hours thereafter.  
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metformin should be avoide din those who...   abuse alcohol, severe CHF, or liver or renal failure.  
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class of a carbose?   alpha glucosidase inhibitor. inihibts the GI tracts ability to degrade carbohydrates, making glucose less available for absoprtion.  
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another alpha glucosidase inhibitor?   miglitol, has same MOA and effects as acarbose  
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MOA of thiazolidinediones?   sensitize skeletal muscle and fat tissue to isulin.  
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MOA of glitazones?   potential to cause edema, weight gain, new onset HF, and exacerbation of pre existing CHF. all are heaptotoxic  
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these are non sulfonylurea secretagogues.   meglitides  
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this category work to promote insulin release from beta islet cells. this MOA has a decreased effect after long term treatment with sulfonylureas.   sulfonylureas  
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this is an analogue of amylin, a rmone released by beta islet cells att eh same tie as insulin is released   pramlintide.  
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FINISH this chapter    
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