Sepsis, Sepsis Syndrome, and Septic Shock
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| Big thing with septic shock ? | * number one cause of ICU deaths
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| Process of Septic Shock ? (already in last lec.) | * Bacterial infection --> Bacteremia --> Host inflammatory response --> Increased Inflammation & Coagulation/Decreased Fibrinolysis --> Changes in endothelium, microvasculature, BP --> Shock & Organ failure
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| Know the Septic definitions from the Bd Culture Lec. | .
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| community-acquired pneumonia cause ? | * Encapsulated pyrogens (strep pneumo)
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| Most common UTI cause ? | * Gram negative rods (E.Coli)
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| Severe burns usually cause ? | * Anaerobes (like Pseudomonas)
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| Special consideration for Pseudomonas ? | * Gram negative bacilli -- Ubiquitous; opportunistic pathogen -- Oxidase + Pigments and toxins ........... * can see in immuncompromised and Neutropenic patients ...... * it has a HIGHER mortality rate is sepsis
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| Good Pseudomonas indicator ? | * Ecthyma gangrenosum lesion ....* looks like a black lesion on the skin
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| Main reason why we get septic shock ? | * results from an overwhelming host mediator response that induces pathologic changes
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| Some host factors that contribute to sepsis ? | * Kinins - PAF - TNF-a - NO - TLR - PGs _ Complement - ILs
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| The coagulation abnormalities seen in sepsis ? | * Get an increase in Coag/Inflam factors and a decrease in fibrinolysis
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| Signs and Symptoms Suggesting Sepsis Syndrome ? | * A patient may feel apprehensive but appear normal, except for slight tachypnea and tachycardia.
...Developing sepsis?
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| Hemo and CV aspects of Sepsis ? | * get leaky vessels due to VD --> SVR .... * HypoTN responsive to refractory fluid retention..... * Get CV insuff. and hypoperfusion.... * Coag issues to that lead to organ damage
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| Patient Management ? | * Shock and Organ Failure - fluids given and normalize CV ...... * Antimicrobial TmT..... * Invasive Procedures to remove the infection/abscess.... * Put Patient in ICU
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| The most important considerations in patient management ? | * Prevention.... Limit the possibilities of a bacteria exposure
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Created by:
thamrick800
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