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gyn-breast medicine

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Question
Answer
each breast contains ___-___ glands/lobules that are separated by adipose tissue   20-40  
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97% of the lymph drainage is via the ______ nodes   axillary  
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Breast tissue consists of...?   lobular, ductal, connective, adipose tissue  
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breast CA is the leading cause of death overall for women aged ____-____   40-59  
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abnormal breast masses are evaluated by ____ in women <30yo and by _____ in women >30yo   sonogram, mammography  
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what age women usually get cysts?   middle aged women  
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PE reveals a palpable, unilateral, soft-firm, round, mobile mass that is often TENDER   cyst  
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how to tx a cyst? what does this tell you?   aspirate the cyst. clear fluid=no further eval. blood/turbid=send to cytology  
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indications for excising a cyst   blood fluid, palpable mass after aspiration, fluid reaccumulates in 2 wks, or cyst recurs even after 2 aspirations  
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a condition where cysts of microscopic or larger size develop in the breasts and surrounding tissue becomes ticketed, bumpy, and fibrous (glandular and ductal tissue may also change)   fibrocystic breast dz/fibrocystic condition  
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fibrocystic breast dz usually occurs in what age women?   middle aged women  
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fibrocystic condition RARELY develops in _________ women   postmenopausal  
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PE of fibrocystic condition?   bilateral, clumpy, mobile, symmetrical masses, and possible multiple masses. tenderness if CYCLIC  
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if dx of fibrocystic condition remains uncertain after sono/mammo, what do you do?   aspirate for biopsy  
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tx of fibrocystic condition should center around what?   alleviation of pain  
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fibroadenomas usually occur in who?   young women (<30yo)  
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PE of a fibroadenoma?   unilateral, round, smooth, mobile, firm/rubbery, usually 1cm or larder, and NON-TENDER  
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if sono/mammo of fibroadenoma leaves any doubt, what do you do?   biopsy w/ fine needle aspiration (FNA)  
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how to tx biopsy-confirmed fibroadenoma?   can be left alone, tx w/ cryoablation of excised if large  
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if a fibroadenoma grows quickly and becomes large (>5cm), what is it called? how do you tx?   phyllodes tumors. requires excision  
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pts w/ breast CA often present with what?   a mass  
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is the CA is progressed, pt may also present with what?   weight loss, anorexia, night sweats, fatigue  
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PE of breast CA?   firm-hard, usually NON-TENDER, difficult to distinguish from surrounding tissue, non-mobile, usually unilateral  
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most breast CA are what?   infiltrating ductal carcinoma  
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crusting, scaling, erosion around the nipple. discharge common. a form of ductal carcinoma   paget disease of the nipple  
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erythematous, warm, peau d'orange skin. axillary lymph nodes palpable but no detectable mass   inflammatory breast carcinoma  
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a new-onset breast mass in women >___ yo, is considered CA until proven otherwise   50yo  
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___-___% of breast CA are a result of BRCA1 and BRCA2   5-10  
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risk-reducing meds for breast CA   tamoxifen or raloxifene  
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if a 1st degree relative had PRE-menopausal breast CA, start annual screen ___ yrs earlier than the CA was first detected in the relative   10  
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HER2/neu is ______ aggressive CA than other cancers w/o this mutation   more  
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hormonal therapy is highly effective in decreasing recurrence in hormone receptor ______ CAs and should be prescribed for ___ yrs follow CA tx.   positive, 5yrs  
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Aromatase inhibitors are only for ________ women w/ hormone receptor _____ CA.   post-menopausal women, positive  
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when is chemo used?   if lymph nodes test positive or tumor is larger than 1cm  
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if biopsy shows HER2/neu over expression there is an indication for what?   chemo plus a tissue-targeted med  
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who should you NEVER give HRT to?   breast CA survivors  
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when should you be concerned about nipple discharge?   blood, unilateral and persistent, associated w/ a mass, or is spontaneous  
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most common cause of bloody nipple discharge? tx?   intraductal papilloma (benign). excise the duct  
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what are some causes of galactorrhea?   high levels of prolactin in blood. caused by pregnancy, a pituitary tumor, hypothyroidism, excessive exercise or a side-effect of certain meds  
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meds that lower _____ levels will trigger a rise in ______ levels   dopamine, prolactin  
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some meds that cause galactorrhea?   antipsychotics, cimetidine, ranitidine, metoclopramine, SSRIs, TCAs, verapamil, opiates  
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if _____ is normal, but prolactin is ______, order a MRI of ____ _____ to evaluate for a ______ tumor   thyroid, high, sella turcica, pituitary  
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mastitis is most often caused by?   Staphylococcus aureus  
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presentation of mastitis? MC in?   localized redness, warmth, tenderness. fever and lymphadenopathy are common. MC in breast feeding women  
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tx of mastitis   Dicloxacillin. pt can continue to breast feed  
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presentation of breast abscess?   localized collection of pus, usually in a blocked milk duct/galactocele  
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tx of breast abscess?   Dicloxacillin. drain the abscess w/ either needle or incision  
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imaging is not usually necessary for breast pain, but if pain is _____, and no cause can be identified or if pt has risk factors, consider imaging   focal (not diffuse)  
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breast extends from the _____ to the _____ _____ and from the _____ to the _______ line   clavicle, 6th rib; sternum, midaxillary  
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best time for breast eam   soon after menses  
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most common location of malignant lesion is in the _______   upper outer quadrant  
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if common reasons for gynecomastia are ruled out order a ______. any detectable level could mean what?   B-hCG. could mean a testicular tumor or other malignancy, or hypogonadism  
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other rare causes of gynecomastia?   Klinefelter syndrome, liver dz, hyperthyroidism, renal failure  
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