Antiviral HIV Pharm
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Life cycle of HIV ? | * binds to CD4+ or CCR5 --> into membrane --> reverse transcrition to make DS DNA --> put RNA in to be into cells
🗑
|
||||
| Antiretroviral drug classes ? | * Nucleoside analogs (NRTIs or nukes)
----Nonnucleoside reverse transcriptase inhibitors (NNRTIs or non-nukes)
----Protease inhibitors (PIs)
----Integrase inhibitors
----Fusion inhibitors
----Entry inhibitors – CCR5 antagonists
🗑
|
||||
| Usu initial combo ? | * 2 nukes + 1 PI or II or NNRTI
🗑
|
||||
| Nucleoside analogs ? | * Lamivudine
---Zidovudine (AZT)
---Stavudine
---Didanosine
🗑
|
||||
| Protease Inhibitors (PIs) ? | * Ritonavir (RTV)
---Indinavir
---Fosamprenavir
---Nelfinavir
---Saquinavir
🗑
|
||||
| Nonnucleoside RT Inhibitors (NNRTIs) ? | * Efavirenz*
----Nevirapine
🗑
|
||||
| Fusion inhibitor ? | * Enfuvirtide
🗑
|
||||
| Entry Inhibitor – CCR5 antagonist ? | * Maraviroc
🗑
|
||||
| Integrase inhibitor ? | * Raltegravir
🗑
|
||||
| Nucleoside analog MOA ? | * incorporates itself as a triphosphate in to the viral DNA to stop viral replication
🗑
|
||||
| Nucleoside analogs Side Effects ? | * minimal drug/drug interactions..... * Black Box Warning --> Lactic acidosis with hepatic steatosis ...... * Zidovudine - bone marrow depression = anemia
🗑
|
||||
| Preferred in pregnant pts ? | * Zidovudine
🗑
|
||||
| Nonnucleoside Reverse transcriptase Inhibitors (NNRTIs) MOA ? | * Same target….but binds to unique site that causes a confirmational change in enzyme so it doesn't work
..... * Bind directly to HIV-RT and are direct acting
🗑
|
||||
| NNRTIs – Advantages ? | * Efavirenz - 1 pill a day..... * Nevirapine - safe in pregnancy
🗑
|
||||
| NNRTIs – Disadvantages ? | * Efavirenz - neuropsych effects, teratogenic,use p450, tons of drud/drug interactions ..... * Nevirapine - hypersensitivity rash and hepatitis
🗑
|
||||
| Protease inhibitors MOA ? | * Competitive inhibition of viral protease, Preventing immature virions from becoming mature
🗑
|
||||
| Addition of ritonavir to Lopinavir ? | * makes Lopinavir a multiple dose a day drug to a one day dosed.... RTV is often used with other PIs to boost them
🗑
|
||||
| PI Drug Interactions ? | * Eliminated by hepatic metabolism (CYP3A4)
so watch in using other drugs that inhibit or induce it
🗑
|
||||
| Toxicity of PIs ? | * GI issues , hepatotoxicity , lipodystroophy (moves fat to other places) , hyperlipidemia , and insulin resistance
🗑
|
||||
| Integrase inhibitor MOA ? | * Blocks HIV integrase from inserting viral genome into host cell DNA..... *given injection SubQ
🗑
|
||||
| Fusion inhibitor MOA ? | * Blocks the entry of HIV-1 into CD4+ cells. ---Binds gp41 subunit HIV envelope glycoprotein
🗑
|
||||
| Fusion inhibitor Side Effects ? | * * Also see little wasp sting reactions where it is injected
🗑
|
||||
| Entry inhibitor MOA ? | * Binds CCR5 and blocks the HIV gp120 from associating with the receptor. HIV is then unable to bind and enter cells .... *
need to do receptor tests bc if HIV binds to other ones, this drug won't work, only on CCR5......
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
thamrick800
Popular Medical sets