First Aid hypersensitivity rxns
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| anaphylaxis | I
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| allergic rhinitis (hay fever) | I
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| asthma | I
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| eczema | I
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| hemolytic anemia | II
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| ITP | II
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| erythroblastosis fetalis | II
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| RF | II
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| Goodpasture's | II
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| bullous pemphigoid | II
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| Grave's | II
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| MG | II
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| SLE | III
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| RA | III
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| polyarteritis nodosum | III
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| post-strep GN | III
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| serum sickness | III
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| arthus rxn | III
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| hypersensitivity pneumonitis | III
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| DM type I | IV
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| MS | IV
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| Guillain-Barre syndrome | IV
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| Hashimoto's | IV
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| graft-vs-host dz | IV
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| PPD | IV
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| contact dermatitis | IV
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| IgE mediated - free Ag cross-links IgE on presensitized mast cells and basophils --> trigger release of vasoactive amines | I
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| Ab mediated - IgM, IgG bind fixed Ag on enemy cell --> lysis by complement or phagocytosis | II
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| immune complex mediated - Ag-Ab complex activates complement --> attract neutrophils --> neutrophils release lysosomal enzymes | III
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| delayed (T-cell) mediated - sensitized T lymphocytes encounter Ag --> release lymphokines --> macrophage activation | IV
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