First Aid hypersensitivity rxns
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| disorder |
 |
|
| hypersensitivity rxn type |
|
|
| anaphylaxis |
I |
| allergic rhinitis (hay fever) |
I |
| asthma |
I |
| eczema |
I |
| hemolytic anemia |
II |
| ITP |
II |
| erythroblastosis fetalis |
II |
| RF |
II |
| Goodpasture's |
II |
| bullous pemphigoid |
II |
| Grave's |
II |
| MG |
II |
| SLE |
III |
| RA |
III |
| polyarteritis nodosum |
III |
| post-strep GN |
III |
| serum sickness |
III |
| arthus rxn |
III |
| hypersensitivity pneumonitis |
III |
| DM type I |
IV |
| MS |
IV |
| Guillain-Barre syndrome |
IV |
| Hashimoto's |
IV |
| graft-vs-host dz |
IV |
| PPD |
IV |
| contact dermatitis |
IV |
| IgE mediated - free Ag cross-links IgE on presensitized mast cells and basophils --> trigger release of vasoactive amines |
I |
| Ab mediated - IgM, IgG bind fixed Ag on enemy cell --> lysis by complement or phagocytosis |
II |
| immune complex mediated - Ag-Ab complex activates complement --> attract neutrophils --> neutrophils release lysosomal enzymes |
III |
| delayed (T-cell) mediated - sensitized T lymphocytes encounter Ag --> release lymphokines --> macrophage activation |
IV |
|
