First Aid hypersensitivity rxns

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disorder
hypersensitivity rxn type
anaphylaxis   I  
allergic rhinitis (hay fever)   I  
asthma   I  
eczema   I  
hemolytic anemia   II  
ITP   II  
erythroblastosis fetalis   II  
RF   II  
Goodpasture's   II  
bullous pemphigoid   II  
Grave's   II  
MG   II  
SLE   III  
RA   III  
polyarteritis nodosum   III  
post-strep GN   III  
serum sickness   III  
arthus rxn   III  
hypersensitivity pneumonitis   III  
DM type I   IV  
MS   IV  
Guillain-Barre syndrome   IV  
Hashimoto's   IV  
graft-vs-host dz   IV  
PPD   IV  
contact dermatitis   IV  
IgE mediated - free Ag cross-links IgE on presensitized mast cells and basophils --> trigger release of vasoactive amines   I  
Ab mediated - IgM, IgG bind fixed Ag on enemy cell --> lysis by complement or phagocytosis   II  
immune complex mediated - Ag-Ab complex activates complement --> attract neutrophils --> neutrophils release lysosomal enzymes   III  
delayed (T-cell) mediated - sensitized T lymphocytes encounter Ag --> release lymphokines --> macrophage activation   IV  


   

 
 

 
 

 

 

 
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