| Flap 1 |
 |
|
| Flap 2 |
|
|
| antipsychotics (neuroleptics) |
haloperidol, -azine |
| atypical antipsychotics |
clozapine, olanzapine, risperidone, apripazole, quetiapine |
| SSRIs |
fluoxetine, sertraline, paroxetine, citalopram |
| TCAs |
impramine, amytriptyline |
| MAOIs |
phenelzine, selegiline, tranylcyprome |
| EtOH withdrawl treatment |
BZD |
| anorexia/bulimia treatment |
SSRI |
| atypical depression |
MAOI |
| bipolar treatment |
mood stabilizers: lithium, valproic acid, carbamazepine |
| depression treatment |
SSRI, TCA |
| depression with insomnia treatment |
trazadone (increases REM), mirtazapine (causes sedation) |
| OCD treatment |
SSRI, clomipramine (TCA) |
| panic disorder treatment |
TCA, busprione |
| schizophrenia treatment |
antipsychotics |
| Tourette's treatment |
haloperidol, olanzapine (atypical antipyschotic) |
| blocks D2 receptors |
antipsychotics (neuroleptics); D2 normally regulates NT release |
| block DA and 5HT(2) receptors |
atypical antipsyhotics |
| inhib phosphoninositol cascade |
lithium |
| stimulates 5HT(1A) receptor |
busprione |
| blocks NE and 5HT reuptake |
TCA |
| block DA, NE, 5HT reuptake |
venlafaxine |
| alpha-2 antag --> increase NE and 5HT release; 5HT(2) and 5HT(3) receptor antag |
mirtazapine |
| blocks NE uptake |
maprotiline |
| inhib 5HT reuptake |
trazadone |
| SE of antipsychotics (neuroleptics) |
EPS, neuroleptic malignant syndrome, tardive dyskinesia |
| EPS side effects |
4 hours dystonia, 4 days akinesia (parkinsonism), 4 weeks akathesia (restlessness), 4 months tardive dyskinesia |
| tardive dyskinesia |
oral-facial movements due to DA receptor sensitization |
| neuroleptic malignant syndrome |
rigidity, myoglobinuria, autonomic instability, hyperpyrexia |
| treatement of neuroleptic malignant syndrome |
dantrolene, DA agonists |
| treatement of positive and negative symptoms of schizophrenia |
atypical anitpsychotics |
| OCD, anxiety, depression, mania, Tourette's treatment |
olanzapine |
| SE: agranulocytosis, requiring weekly WBC monitoring |
clozapine |
| SE: tremor, nephrogenic DI, hypoTN, pregnancy problems |
lithium |
| anxiolysis for generalized anxiety disorder; no sedation or addiction, no interaction with EtOH |
busprione |
| caused by taking SSRI and MAOI together |
serotonin syndrome |
| serotonin syndrome |
hyperthermia, muscle rigidity, CV collapse |
| SE: convulsions, coma, cardiotoxicity |
TCAs |
| used in smoking cessation |
bupropion |
| antidepressant that does NOT cause sexual SE |
bupropion |
| SE: increase REM, priapism |
trazadone |
| treatment for depressed elderly patient who is losing weight |
mirtazapine (SE: increased appetite) |
| contraindicated in treatement of depressed bulimic patient |
bupropion --> decreases seizure threshold |
| contraindicated with tyramine ingestion and B-agonists --> hyperthermia |
MAOI |
| contraindicated with SSRI and meperidine --> serotonin syndrome |
MAOI |
