| Flap 1 |
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| Flap 2 |
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| Dz associated w/ anti-acetylcholine receptor? |
myasthemia gravis |
| Dz assoc. w/ anti-centromere Ab? |
CREST Sx 60% and PSS 10% |
| Dz assoc. w/ anti-gliadin Ab? |
Celiac Dz (95%) |
| Dz assoc. w/ anti-glomerular basement membrane? |
Goodpasture Sx (90%) |
| Against what Ab is anti-GBM directed to? |
Collagen Type IV |
| What Dz is assoc. w/ anti-islet cel Abs? |
Type I DM |
| What Dz is assoc. w/ anti-microsomal Abs? |
Hashimotos (97%) autoimmune hepatitis (70%) |
| Dz. assoc. w/ anti-mitochondrial Abs? |
primary biliary cirrhosis (90-100%) |
| Dz. assoc w/ C-ANCA? |
Wegner's Granulnomatosis |
| Dz. assoc. w/ P-ANCA? |
Polyarteritis Nodosa (PAN) and Hep B associated to PAN |
| Dz. assoc. w/ anti-parietal cell Abs? |
Pernicious Anemia |
| Dz. assoc. w/ intrinsic factor Abs? |
Pernicous Anemia Type I (Ab to B12 prevent binding to IF) Type II (Ab to IF or complex) |
| Dz. assoc. w/ anti-smooth muscle Abs? |
Autoimmune Hepatitis (70%) |
| Dz. assoc. w/ anti-thyroglobulin Ab? |
Hashimoto (85%) Grave's (30%) |
| What Dz is associated w/ myasthemia gravis? |
thymoma (60%) |
| HLA relationship of hemochromatosis? |
A3 |
| HLA relationship of Myasthemia Gravis? |
B8 |
| HLA relationship of Celiac Dz? |
B8 and DR3 |
| HLA relationship of Ankylosing Spondylitis? |
B27 |
| HLA relationship of Multiple Sclerosis? |
DR2 |
| HLA relationship of Type I DM? |
DR3 and DR4 |
| HLA relationship of Rheumatoid Arthritis? |
DR4 |
| What is the MCC of Autoimmune Hemolytic Anemia? |
Warm IgG Lupus |
| 2nd MCC of Hemolytic Anemia? |
Drug Induced Hemolytic Anemia |
| What two drugs used for HT for pregnancy? |
Hydralazine, Methyl-Dopa |
| Hydralazine causes? |
Drug Induced Lupus |
| MC drug that causes drug-induced Lupus? |
Procainamide |
| What Ab is made against alpha-methyl dopa? |
IgG G is for Gravida |
| What Ab is made against Quinide? |
IgM |
| What does IgG activate? |
Macrophages to become active |
| What does IgM activate? |
Complement System MAC C1-C9 |
| What disease causes leukemoid reaction? |
B. pertussis Scares Pediatricians!!! >60,000 WBCs |
| Mononucleosis caused by ------> |
EBV |
| What cell does EBV infect? |
B-Cell |
| What is the marker (receptor) for EBV, B-cells? |
CD21 |
| What drug induces atypical lymphocytes? |
phenytoin |
| MOA of Phenytoin? |
Blocks intestinal Conjugase |
| What drug causes macrocytic anemia and atypycal lymph? |
Phenytoin |
| Where does EBV hide for the rest of the life of the patient? |
Salivary Glands Kissing Disease |
| What test is diagnostic for Mononucleosis? |
Anti Heterophile Antibody |
| What diseases cause eosinophilia? |
Strongyloides Malaria Type I Yes whipworm |
| MCC of Bud-Chiari Sx? |
polycytemia vera |
| Age of ALL? |
0-15 |
| Age of AML? |
15-40 40-60 |
| Age of CLL? |
>60 |
| Age of CML? |
40-60 |
| MC overall Leukemia? -------> |
CLL |
| Characteristic of CLL? |
MC generalized non-tender lymphadenopathy >60y ? |
| MC Leukemia >60yo? |
CLL |
| Where does CLL metastisize to? |
lymph nodes |
| 49 y.o. 150,000 WBC 1% myeloblasts (<30% blasts) generalized lymphadenopathy |
CML |
| Translocation of CML? |
t9;22 of abl gene |
| 49 y.o. 150,000 WBC 1% myeloblasts (<30%) generalized lymphadenopathy |
CML |
| What gene/chromosome is important in CML? |
Philadelphia Chromosome 22 |
| What translocation is seen in CML? |
t9;22 |
| What is the gene in t9;22? |
bcr-abl gene |
| What two tests are used to Dx CML? |
Philadelphia Chromosome (+) and LAP (low level) LAP = leukocyte alkaline phosphatase not absorbed by malignant cells |
| What do is the Dx when you see a tear drop cell? |
Agnogenic Myeloid Metaplasia |
| Pt. 4yo, w/ generalized non-tender lymphadenopathy, sternal tenderness, hepatosplenomegaly, fever, normocytic anemia, 50,000 WBCs abnormal appearing cells |
ALL |
| What antigen is use to detect ALL? |
CALLA |
| What does CALLA detect? |
B-cells CD10 |
| Pt. 65 yo man, hepatosplenomegalic, 90,000 WBC smudge cells, also pt. has hypogammaglobulinemia |
CLL age gives it away |
| What leukemia has auer rods in it? |
AML |
| What leukemia has lots of auer rods? |
Acute Promyelocytic Leukemia (M3) |
| What are the four/five myeloproliferative dz? |
1. polycythemia vera 2. chronic myelogenous leukemia 3. adenogenic myeloid metaplasia 4. essential thrombocytemia myelodysplastic Sx |
| What are the four H's of polycythemia vera? |
1) Hyperviscosity 2) Hypervolemia 3) Histaminemia 4) Hyperuricemia |
| What is the Dx of a patient that complains of itching after taking a shower hot or cold? |
Polycythemia ruba vera |
| What is the translocation of Burkitt's Lymphoma? |
t8;14 |
| What is responsible for Burkitt's Lymphoma? |
EBV |
| What do you see in the pathology slides for Burkitt's? |
Starry Sky Appearance |
| What are the three K for Burkitt's? |
Kid 8yo 8 is for translocation 8;14 blacK C-Myc |
| What are the stars in Burkitt's? |
Macrophages |
| United States where is Burkitt's Located? |
Abdomen (Peyer's Patches, Paraortic Lymph nodes), Testicle also |
| African Burkitt's lymphoma MC location? |
Jaw |
| What two tissues are resistant to cancer infection? |
Cartilage and Elastic Vessels |
| Pat. w/ plaque like lesions w/ inflamatory cells in epidermis? |
Neoplastic epidermis cells Helper T-Cells Mycosis Fungoides |
| What is a helper T-cell malignancy that involves skin? |
Mycosis Fungoides |
| What cell is involved in Mycosis Fungoides? |
Sezary Body |
| What is a sezary body? |
Helper T-cell seen in plasma of pat. w/ Mycosis Fungoides |
| What substance is secreted and produced by Gastic Adenocarcinoma (Linitis Plastica)? |
Mucin Producer |
| What is the appearance of the stomach in linitis plastica? |
diffusely inflitrative (thickened appearance) mucosa and muscularis produced rigid thick, leather-bottle gastric wall |
