hematology Ch 1 to 4
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| What is the average M:E (myelocyte:erythrocyte) ratio for normal adult none narrow? | 3:1 to 4:1
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| the key organs involved in extramedullary hematopoiesis include: | liver and spleen
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| which is the best test to assess the bone marrow's response to anemic stress | reticulocyte count
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| anybody-coated red cells that have their antibodies stripped in the spleen usually reappear in the circulation as: | spherocyte
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| a peripheral blood indicator of ineffective bone marrow is | polychromatophilic macrocytes (reticulocyte)
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| the hormone responsible for signaling red cell development in | epo (erythropoietin)
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| what is the perfect size for bone marrow aspiration and biopsy | iliac crest
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| a Wright-stained smear of a patient with an elevated reticulocyte count should show | large red bluish cells, polychromatophilic macrocytes
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| one of the key of morphological features of the nucleus red cell stage is | baseball round nucleus
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| the red cell protein that is responsible for the deformabillity and flexibility of the red cell is | spectrin and ankyrin
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| increased plasma cholesterol may lead to the development of which of these abnormal red cell morphologies | target cells
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| which of the following RBC pathways is responsible for providing 90% of the cellular ATP for red cell metabolism | embden-meyerhof (EM) pathway
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| the hemoglobin molecule consists of | 4 heme molecules with iron at the Center (2 pairs) 2 pairs of globin chains
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| When hemolysis is produced by intravascular fragmentation of red cells, which red cell morphology will be produced? | schistocytes
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| Reversible sickled cells are described as having a | half moon with no pointed projections
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| What percent of hemoglobin is synthesized in the reticulocyte stage | 35%
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| Epsilon and zeta chains are part of which hemoglobin? | Gowers 1 & 2 and Portland
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| Which abnormal hemoglobin will result in a cyanotic condition? | methemoglobin aka Hgb M
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| The hemoglobin molecule will either hold onto or release oxygen depending on the | venous pulmonary circulation to arterial
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| how many genes are responsible for the production of alpha chains? | 4
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| Fetal hemoglobin consist of what | Hgb F (A2Y2) 'alpha2 gamma2'
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| Which organs are the most affected during extravascular lysis | spleen, liver, lymphnodes, and bone marrow
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| The degree of effective erythropoietic (production of RBCs) activity in any hematological disorder is most readily assessed by the | increased reticulocyte count
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| The red cell inclusion derived from denatured hemoglobin is | Heinz bodies
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| Polychromatophilic macrocytes in the peripheral smear are defined as | reticulocytes
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| The last nucleated stage of erythrocytic maturation is | orthochromic normoblast aka matarubicocyte aka nucleated RBC
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| What clinical condition is a definitive sign of intravascular lysis | hemoglobinemia
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| What is the most useful corrective action for the microscope when details cannot be visualized in immature cells | Use 100x and open diaphragm
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| Behaviors that are standard precautions are: | wearing PPE and treating every patient as if infected
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| Standards and calibrators differ from control materials because | -standards are solutions that have a known amount of analyte and used to calibrate the instrument
-Controls are used to monitor the performance after calibration and mimics patient samples
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| Proper mixing of samples and timely delivery of samples to the laboratory are both examples of what type of lab variable | preanalytical
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| A delta check is a historical reference on samples run in the lab. Once a sample fails a delta check, the most obvious corrective action is to | repeat
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| delta checks, results released, critical results released, specimen checked for clotting, and reflex testing initiated are common examples of what type of lab variable |
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| Error analysis, standard protocols, and turnaround time are all part of the: | QA (quality assurance)
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| The average of a group of delta points is defined as the | mean
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