Adaptive Immunity

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Adaptive Immunity

Involves the ability to recognize, respond to, and remember a particular substance

Stimulants and Types of Adaptive Immunity

-Stimulants> *Antigens: Large molecules **Foreign: Not produced by body, introduced from outside **Self-antigens: Produced by body **Haptens: Small molecules and capable of combining =Types *Humoral or Antibody-mediated: B cells *Cell-mediated:tcel

Origin and Development of Lymphocytes

B and T cells --Originate in red bone marrow --Move to lymphatic tissue from processing sites and continually circulate ---Clones are small groups of identical lymphocytes

Origin and Development of Lymphocytes II

Positive selection= Ensures survival of lymphocytes that react against antigens -Negative selection= Eliminates lymphocytes that react against self-antigens

Origin and Development of Lymphocytes III

Primary lymphatic organs (red bone marrow, thymus)= Where lymphocytes mature into functional cells --Secondary lymphatic organs =Where lymphocytes produce an immune response

Major Histocompatability Complex (MHC) -Most lymphocyte activation involves glycoproteins of cell surfaces called MHC molecules

--Class I molecules display antigens on surface of nucleated cells, resulting in destruction of cells --Class II molecules display antigens on surface of antigen-presenting cells, resulting in activation of immune cells