Exam 6: Meds that affect the GI (N/V)
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Dimenhydrinate | Dramamine
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| Dimenhydrinate uses | Prevention & treatment of nausea, vomiting, dizziness, vertigo of motion sickness
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| Dimenhydrinate Adverse Reactions | Dizziness, confusion, nervousness, restlessness, nausea, vomiting, diarrhea, blurred vision, palpitations
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| 50-100 mg PO q4-6hr prn, max dose, 400mg/d, 50mg IM prn, 50mg IV | Dimenhydrinate Doseage
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| Diphenhydramine | Benadryl
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| Diphenhydramine uses | Prevention & treatment of motion sickness, antihistamine
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| Diphenhydramine Adverse Reactions | Dizziness, SEDATION, Epigastric Distress, faintness, allergic reactions, urinary frequency, thickening of bronchial secretions.
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| 25-50mg PO q4-6hr, 10-50mg IM, IV | Diphenhydramine Doseage
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| Dolastron Mesylate | Anzemet
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| Dolastron Mesylate uses | Prevention of chemo-induced N/V, postoperative N/V
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| Dolastron Mesylate Adverse Reactions | Hypotension, hypertention, EKG changes, HA, dizziness, sedation, hunger, constipation
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| Before chemo: 100mg within 1hr., PO N/V: 100mg or 1.8mg/kg IV | Dolastron Doseage
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| Granisetron Hydrochloride | Kytril
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| Granisetron Hydrochloride Uses | Prevention & Treatment of N/V due to antineoplastic drug therapy
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| Granisetron Hydrochloride Adverse Reaction | HA, weakness, somnolence, diarrhea, constipation
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| 10mcg/kg infused IV over 5min, 30min before chemo. or 1mg PO BID | Granisetron Hydrochloride Doseage
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| Meclizine | Antivert
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| Meclizine Uses | Vertigo, prevention & treatment of N/V due to motion sickness, Menirere's Disease
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| Meclizine Adverse Reactions | Drowsiness, restlessness, rash, uticaria, anorexia, hypotension, dry mouth, nose and throat
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| Vertigo: 25-100mg/d PO in divided doses; N/V: 25-50mg PO 1hr before travel and repeat 24h PRN | Meclizine Doseages
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| metoclopramide | Reglan
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| metoclopramide uses | Prevention of N/V due to antineoplastic drug therapy, promote gastric emptying
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| metoclopramide adverse reactions | Restlessness, drowsiness, fatigue, lassitude, dizziness, nausea, diarrhea
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| 1-2mg/kg IV 15-30min before chemotherapy | metoclopramide Dosage
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| Ondansetron | Zofran
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| Ondansetron Uses | Prevention of N/V due to antineoplastic drug therapy, postoperative N/V
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| Ondansetron Adverse Reactions | Diarrhea, HA, fever, weakness, dry mouth, drowsiness, sedation
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| Chemo. 3 doses of 0.15mg.kg IV or 32mg PO 30min before chemo. post-op N/V; 4mg IV | Ondansetron Dosage
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| Promethazine Hydrochloride | Phenergan
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| Promethazine Hydrochloride Uses | Tx of motion sickness
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| Promethazine Hydrochloride Adverse Reactions | Dizziness, sedation, epigastric distress, faintness, allergic reactions, urinary frequency, thickening of bronchial secretions
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| Motion sickness: initial 25mg PO 1/2 before travel and repeat in 8-12hr; N/V 12.5-25mg PO, IM, IV | Promethazine Hydrochloride Dosage
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| Transdermal Scopolamine | Transderm-Scop
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| Transdermal Scopolamine Uses | Prevention of N/V due to motion sickness
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| Transdermal Scopolamine Adverse Reactions | Drowsiness, dry mouth, blurred vision
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| One system applied at least 4hr before effect is required, repeat in 3d if needed | Transdermal Scopolamine Dosage
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| Trimethibenzamide Hydrochloride | Tigan
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| Trimethibenzamide Hydrochloride Uses | Control of N/V
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| Trimethibenzamide Hydrochloride Adverse Reactions | Hypotension (IM use) Parkinson-like symptoms, blurred vision, drowsiness, dizziness
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| 250mg PO TID, QID: 200mg IM, rectal suppository TID, QID | Trimethibenzamide Hydrochloride Dosage
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| Prochlorperazine Hydrochloride | Compazine
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| Prochlorperazine Hydrochloride Uses | Control of N/V
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| Prochlorperazine Hydrochloride Adverse Reactions | Drowsiness, hypotension, postural hypotension, bradycardia, dry mouth, nasal congestion
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| 5-10mg PO TID, QID; 10-20mg IM, IV; 25mg rectal suppository BID; 10-15mg sustained release | Prochlorperazine Hydrochloride Dosage
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