multiple endocrine neoplasia
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| MEN stands for: | multiple endocrine neoplasia
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| MEN is: | disorders of endocrine excess; group of hereditary syndromes characterized by aberrant growth of malignant and benign tumors in multiple endocrine glands
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| MEN syndromes include: | Wermer syndrome (MEN-1); Sipple syndrome (MEN-2a); Mucosal neuroma syndrome (MEN-2b)
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| Wermer syndrome (MEN-1) 3 P's: | pituitary, parathyroid, pancreas (also facial angiofibromas)
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| Sipple syndrome (MEN-2a): | medullary thyroid carcinoma, parathyroid, pheochromocytoma
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| Mucosal neuroma syndrome (MEN-2b): | medullary thyroid carcinoma, pheochromocytoma, mucosal and GI ganglioneuromas, (parathyroid tumor is rare)
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| Which is more common: MEN-1 or MEN-2? | MEN-1
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| Which is more common: MEN-2a or MEN-2b? | MEN-2a
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| Which of the 3 MEN forms is more aggressive with a worse prognosis? | MEN-2b
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| MEN-1 treatment | hypercalcemia (surgery); gastrinoma (PPIs); insulinoma (surgery, diazoxide); glucagonoma (surgery); prolactinoma (dopamine agonist); GH (trans-sphenoidal surgery)
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| Most common clinical manifestation of MEN-2: | medullary thyroid carcinoma
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| Second most common clinical manifestation of MEN-2: | pheochromocytoma
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| Common in MEN-2a but not in MEN-2b: | parathyroid tumors
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| MEN-2 treatment | total thyroidectomy with radical lymph node dissection (for medullary thyroid carcinoma); surgical excision under alpha-adrenergic blockade (for pheochromocytoma)
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Created by:
Carrie D.
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