Viral infections of the respiratory tract, Influenza 1/9/13
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| What makes Orthomyxoviruses different from other RNA viruses | It replicates in the nucleus (only other one is HIV)
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| Each segment of a Orthomyxovirus contains how many genes | 1- this promotes mixing and new viruses
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| Two primary surface proteins in Orthomyxovirus | Hemagglutinin and Neuraminidase
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| Hemagglutinin is responsible for | Absorption to cell receptors, the "attachement" protein
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| Which protein is the site for antibody response | HA
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| Which protein undergoes the most antigenic variation? | HA
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| What is the attachment site for HA | Sialic acid
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| Target protein for antivirals? | NA
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| Which antigen is responsible for typing of influenza? | S-Ag
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| Animal known as the "mixing vessel" between avian flu and human flu | Pig
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| Antigenic drift | Gradual, small changes in hemagglutinin and/or Neuramoinidase at a single antigenic determinants, due to point mutations
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| Antigenic shift | Abrupt, following dual infections, major change in many or all antigenic determinants of HA or NA
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| Intragenomic recombination | Crossover
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| Intergenomic recombination | Segment exchange between animal and human virus
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| Highest incidence of Orthomyxoviruses | Age 5-14, winter months
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| Spread mechanism of Orthomyxoviruses | Respiratory droplets
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| Length of immunity in Orthomyxoviruses | 2-4 years due to IgA
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| Orthomyxovirus vaccination includes what | 2 type A and one type B strains
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| Zanamivir and Oseltamivir are used for | Theraputics for Orthomyxoviruses to inhibit viral NA
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| Amatadine and Rimantidine are not effective against | H1N1
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Created by:
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