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Trematodes and Cestodes

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Question
Answer
Definitive host of Schistosomes   Humans  
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Intermediate host of Schistosomes   Snails  
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Where do adult Schistosomes inhabit in the human body?   Portal and Mesenteric vessels  
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Species of Schistosoma that infect humans   (1) Schistosoma mansoni (2) Schistosoma japonicum (3) Schistosoma haematobium (4) Schistosoma mekongii (5) Schistosoma intercalatum (6) Schistosoma malayi  
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Geographic distribution of Schistosoma mansoni   Arabia, Africa, South America, Caribbean  
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Geographic distribution of Schistosoma japonicum   Japan, China, Philippines  
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Geographic distribution of Schistosoma haematobium   Africa, Middle East  
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Geographic distribution of Schistosoma mekongii   Southeast Asia  
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Geographic distribution of Schistosoma intercalatum   West and Central Africa  
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Geographic distribution of Schistosoma malayi   Penang Peninsula and Malaysia  
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Geographic location of 80% of Schistosoma infections worldwide   Sub-Saharan Africa  
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(T or F) Each schistosome species and also strains require a specific species of snail intermediate host.   True. Infections in the US cannot be transmitted due to lack of appropriate snail species.  
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(T or F) Most Schistosomiasis infections are asymptomatic.   True.  
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Bilharzia or Bilharziosis   Clinical presentation of Schistosomiasis  
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Three major syndrome of Schistosomiasis infection   (1) Dermatitis (Swimmer's itch) (2) Acute schistosomiasis (Katayama fever) (3) Chronic Schistosomiasis  
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Schistosomiasis infection syndrome caused by penetrating cercariae presenting with a papular pruritic rash   Dermatitis (Swimmer's itch)  
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Schistosomiasis syndrome occuring when worms have matured and egg deposition begins. Syndrome presents with serum sickness-like syndrome.   Acute schistosomiasis or Katayama fever  
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Most common signs and symptoms of Acute schistosomiasis or Katayama fever   (1) Fever (2) Cough (3) Lymphadenopathy (4) Eosinophilia  
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Antaomical location of Shistosomiasis haematobium lesions   Bladder and Ureters  
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A Schistosomiasis infection syndrome associated with mature worms and heavy egg deposition. The syndrome is characterized by granuloma formation, most commonly in the liver and intestines.   Chronic Schistosomiasis  
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Signs and symptoms of Chronic Schistosomiasis   (1) Fatigue (2) Abdominal pain (3) Diarrhea or Dysentery (4) Heptosplenomegaly (5) Hematuria or Hematemesis  
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Symmer's Pipestem Fibrosis   Granulomatous response in the liver leading to continuous fibrosis  
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Type of samples needed for microscopic detection of Schistosomiasis eggs   Stool or Urine (Schistosomiasis haematobium)  
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Diagnosis of Schistosomiasis Infection   (1) Obtain history of travel and contact with water (2) Microscopic egg detection in stool or urine (3) ELISA test for adult worm antigens  
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Treatment of all six species of Schistosomiasis   Praziquantel  
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Clinical workup of confirmed Schistosomiasis infection   (1) Liver function tests (2) Heaptic and/or urinary tract imaging  
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A parasite of fish-eating mammals in the Far East. Humans become infected by consuming under cooked, pickled, or raw fish. Infection associated with increased incidence of cholagiocarcinoma.   Clonarchis sinesis (Chinese liver fluke)  
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Intermediate host of clonarchis sinesis   Snails  
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Clinical symptoms of Clonorchiasis   (1) Upper right quadrant pain (2) Anorexia (3) Weight loss  
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Pathophyisology of Clonorchiasis   Adult Clonarchis sinensis worms inhabit the bile ducts causing localized obstruction and thickening of the bile duct walls. This results in cholangitis and cholangiohepatitis.  
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Treatment of choice for Clonorchiasis   Praziquantel  
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Liver fluke that primarily infect cats and dogs   Opisthorchiasis  
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Geographic distribuation of Opistrhochis felineus   South East Asia  
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Geographic distribution of Opistrhochis viverrini   Thailand  
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Geographic distribution of Fasciola hepatica   South America, Europe, Africa, China, and Australia  
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Liver fluke in humans associated with watercress consumption   Fascioliasis hepatica  
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Natural hosts of Fasciola hepatica   Sheep, cattle and sometimes humans  
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Clinical signs/symptoms of Fascioliasis   Early infection: (1) Right upper quadrant pain (2) Hepatomegaly (3) Eosinophilia. Later stages of infection: (1) Bile duct obstruction (2) Biliary cirrhosis  
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Treatment of choice for Fascioliasis   Triclabendazole  
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Common signs/symptoms of intestinal fluke infection   (1) Diarrhea (2) Abdominal pain (3) Signs of malabsorption  
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Intestinal fluke found in Southeast Asia and the Far East. Its metacercariae encyst on aquatic plants   Fasciolpsis buski  
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Intestinal fluke found in the Nile delta, Far East, and Southeast Asia. Its metacercariae encyst in freshwater or brakish fish.   Heterophyes heterophyes  
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Geographic distribution of Paragonimus westermani   Western Africa, Far East, Indian subcontinent, and Central and South America  
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Type of trematode that resides in the lung parenchyma. Typically causes infects humans after ingesting undercooked crabs and crayfish.   Paragonimus westermani  
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Clinical signs and symptoms of Paragonimiasis   (1) Eosinophilia (2) Productive cough with brownish sputum (3) Intermittent hemoptysis (4) Chronic bronchitis (5) Pleuritic chest pain  
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Treatment of choice for Paragonimiasis   Praziquantel and corticosteroids  
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Why must corticosteroids be simultaneously be administered with praziquantel for Paragonimiasis?   Dying worms may cause seizures or other neurological complications with neuroparagnimiasis.  
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Scolex   Head of a cestode (tapeworm)  
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Strobila   Tail of a cestode (tapeworm). Consists of a chain of independent proglottids.  
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Intermediate and definitive host of Taenia saginata   Intermediate host: cattle Definitive host: human  
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Intermediate and definitive host of Taenia solium   Intermediate host: Pigs, humans, dogs Definitive host: Humans  
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Intermediate and definitive host of Diphyllobothrium latum (Fish tapeworm)   Intermediate host: Copepods then fish Definitive host: humans  
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Intermediate and definitive host of Hymenolepsis nana (Dwarf tapeworm)   Intermediate host: Humans Definitive host: Humans  
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Intermediate and definitive host of Echinococcus granulosus   Intermediate host: Sheep, cattle, humans Definitive host: Dog  
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Intermediate and definitive host of Echinococcus multilocularis   Intermediate host: Rodents, humans Definitive host: Dog  
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Geographic distribution of Taenia saginata (Beef Tapeworm) infections   Central Asia, Near East, Central and South America  
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Mode of human infection by Taenia saginata   Humans infected after consumption of under cooked beef with Taenia saginata cysts.  
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Clinical symptoms of Taenia saginata infection   (1) Mild abdominal cramps (2) Malaise  
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Treatment of choice for Taenia saginata infection   Praziquantel or niclosamide  
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Diagnosis of Taenia saginata   Stool examination for several days for evidence of Taenia saginata eggs and proglottids.  
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Geographic distribution of Taenia solium infection   Mexico, Central and South America, Africa, Southeast Asia, India, Philippines, and Southern Europe  
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Mode of human tapeowrm infection by Taenia solium   Human infection caused after consumption of under cooked poork with Taenia solium cysts  
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Mode of cysticercosis infection   Humans infected by ingesting eggs becoming the intermediate host. Ingested eggs develop into tissue cysts.  
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The most common parasitic disease of CNS characterized by seizures, hydrocephalus, parses, meningitis, mental deterioration, and coma.   Neurocysticercosis caused by Taenia solium cysts in the CNS.  
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Diagnosis of neurocysticercosis   Radiological evidence of cysts  
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Treatment of choice of Taenia solium tapeworm infection   Praziquantel or niclosamide  
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Treatment options for Cysticercosis   Albendazole, praziquantel, or surgical removal of cysts  
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(T or F) Intraocular cysticercosis can be treated with albendazole or praziquantel.   False. Intraocular cysticercosis should not be treated with drugs.  
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Highly endemic areas of Diphyllobothrium latum infection   Europe, North America, Siberia, Japan and Chile  
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Cestode infection resulting from ingestion of under cooked fish with cysts. Symptoms include abdominal discomfort, salt craving, and diarrhea. May also cause B12 deficiency anemia.   Diphyllobothrium latum (Fish tapeworm)  
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Diagnosis of Diphyllobothrium latum tapeworm infection   (1) Contrast studies of intestine (2) Stool examination for proglottids or eggs  
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Treatment of choice for Diphyllobothrium latum tapeworm infection   Praziquantel or niclosamide and Vitamin B12 supplements  
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Endemic areas of Hymenolepsis nana tapeworm infections   Asia, Southern and Eastern Euorpe, Central and South America, and Africa  
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Mechanism of transmission of Hyemnolepsis nana infections   (1) Human to human (2) Fecal-oral or autoinfection  
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Diagnosis of Hymenolepsis nana tapeworm infection   Stool examination for Hymenolepsis nana eggs  
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Treatment of choice for Hymenolepsis nana tapeworm infection   Praziquantel or niclosamide  
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Mechanism of human infection by Echinococcosis   Humans are inadvertent intermediate hosts, ingest eggs by contamination with feces canines infected with the tapeworm.  
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Most common anatomical sites of hydatid cysts of Echinococcus granulosus   Liver (50-70%) and lungs (20-30%)  
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Symptoms of Hydatid cyst disease   (1) Mass effects due to enlargin cysts (2) Bacterial infections secondary to obstruction (3) Allergic reaction ot parasite antigens  
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Where do new Echinococcus granulosus larvae (scolices) develop?   Larva form a central cyst with a germinal layer from which new larvae (scolices) develop. Cysts can rupture and disseminate scolices, seeding other organs.  
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Treatment of choice for Hydatid cyst disease   Albendazole or mebendazole. Surgical resection of cyst may be possible, but must take care not to rupture the cyst.  
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Geographic distribution of Echinococcus multilocularis alveolar cyst disease   Europe, Asia, and North America  
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Most common anatomical site of Alveolar cyst disease   Cysts are usually found in the liver.  
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Treatment of choice of Alveolar cyst disease   Surgical removal and adjunct albendazole therapy  
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