Mabs, immunomodulators
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
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| Orthoclone OKT3 – | Muromonab CD3 | CD3, T cells | prevent acute rejection of kidney, liver and heart transplants
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| Centoxin – | Nebacumab | lipid A polysaccharide portion of Gm- endotoxin | Severe sepsis that has progressed to endotoxic shock
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| Abciximab | Reopro | GP IIb/IIIa receptor (member of integrin family) | pts. w/ heart disease caused by poor blood flow in arteries of heart
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| Palivizumab | Snygas | RSV | prevention of serious lower respiratory infection caused by RSV
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| Adalimumab | Humira | TNF alpha | (blank)
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| Daclizumab | Zenapax | alpha subunit of IL-2 receptors (activated Tcells) | kidney transplantation
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| Basiliximab | Simulect | alpha subunit of IL-2 receptor | impairs immune response to antigen challenge
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| Infliximab | Remicade | TNF alpha | rheumatoid arthritis and crohn’s disease
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| Efalizumab | Raptiva | LFA-1 to ICAM-1 | treatment of psoriasis
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| Rituximab | Rituxan | CD20 antigen | B cell lymphoma (CD20+), and non-Hodgkin’s lymphoma
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| Trastuzumab | Herceptin | (HER-2) | treatment of breast cancer
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| Alemtuzumab | Campath | CD52 receptor | B cell chronic lymphocytic leukemia
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| Gemtuzumab – ozogamacin | Mylotarg | CD33 receptor | treatment of CD33 positive acute myeloid leukemia
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| Ibritumomab | Zevalin | CD20 | B cell non-Hodgkin’s lymphoma
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| Tositumomab | Bexxar | CD20 receptors | non-Hodgkin’s lymphoma
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| Panitumumab | Vectibix | epidermal growth factor receptors | colorectal cancer pts
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| Centuximab | Erbitux | epidermal growth factor receptors (HER1 | head, neck and colorectal cancers
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| Bevacizumab | Avastin | vascular endothelial growth factor (VEGF) | malignant colon or rectal cancer
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| Cyclosporine | (blank) | targets calcineurin by binding with cyclophyllin | all tissue transplantations
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| Tacrolimus | (blank) | binds to calcineurin via fk506 | Tissue transplantation
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| Rapamycin | Sirolimus | FKPB (FK506) | tissue transplantations, cancer—causes apoptosis
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| Everolimus | (blank) | - inhibits P7056 | Prevention of graft rejection
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| Fingolimod (FTY 720) | (blank) | modulator of spingosine 1-phosphate receptor | (blank)
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| Mycophenolate Mofetil | (blank) | (blank) | (blank)
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