Interstitial Renal Disease
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Definition of Acute Interstitial (Hypersensitivity) Nephritis | Acute renal failure with interstitial inflammatory cells (activated T-lymphocytes and/or eosinophils) and interstitial edema
🗑
|
||||
| Main Causes of AIN? | Idiopathic, Drugs, Infection, Toxins, Immunologic Disease
🗑
|
||||
| What are some Drugs that can cause AIN | NSAIDS, Methicillin, Some Antibiotics, and diuretics (furosemide and thiazide)
🗑
|
||||
| What is the mechanism of AIN | Allergic hypersensitivity
🗑
|
||||
| How long does it take AIN to develop | several weeks
🗑
|
||||
| Definition of Chronic Interstitial Nephritis (CIN) | Chronic renal failure with mixed chronic inflammatory cell infiltrate in interstitium, tubular atrophy and fibrosis
🗑
|
||||
| What is the mechanism for CIN | Physical or Chemical with precipitation of substances in the medulla or ischemic due to drug induced vascular changes
🗑
|
||||
| What are the main causes of CIN | Drugs (NSAIDS, Analgesics, Lithium), Urinary Tract Obstruction, Kidney stones/infection, Polycystic Kidney Disease
🗑
|
||||
| What is the gross pathology of CIN | asymmetrically scarred small shrunken kidneys, sometimes with papillary necrosis with NSAIDS/acetaminophen
🗑
|
||||
| What is the most common bacteria responsible for Ascending infection in pyelonephritis | E. coli
🗑
|
||||
| Define Pyelonephritis | Infection involving the parenchyma, calyces and pelvis
🗑
|
||||
| Define Chronic Pyelonephritis | Multiple episodes of infection secondary to vicoureteral reflux with chronic renal damage or secondary to obstruction
🗑
|
||||
| What is the gross pathology of chronic pyelonephritis | small kidneys with coarse scars, dilated papillae, parenchymal atrophy
🗑
|
||||
| Define ATN (acute tubular necrosis) | Acute renal failure secondary to tubular damage
🗑
|
||||
| What are the four main causes of ATN | Ischemic, Post-transplantation, Toxic, and Obstructive
🗑
|
||||
| What are the three phases of ATN | Oliguric, Diuretic, Regenerative
🗑
|
||||
| What makes someone predisposed to papillary necrosis | long term analgesic use, dibetic with pyelonephritis, and sickle cell anemia
🗑
|
||||
| What is the etiology of calcium oxalate or phosphate kidney stones | idiopathic
🗑
|
||||
| what is the etiology of struvite/magnesium ammonium phosphate kidney stones | Infection
🗑
|
||||
| What are the three "urias" that can result in urolithiasis | Hypercalciuria, Hyperuricosuria, and cystinuria
🗑
|
||||
| What are the kidneys like in patients with ADPKD (Autosomal Dominant Polycystic Kidney Disease) | very large cystic kidneys with round cysts of variable size and no dysplasia (all parts of nephron invoved and bilateral)
🗑
|
||||
| Where else do you see cysts in pts with ADPKD | liver, spleen, pancreas (no effect on function)
🗑
|
||||
| What are two other associated problems in patients with ADPKD (Cardiovascular) | Mitral valve prolapse (25%) and Cerebral Aneurysms (10-20%)
🗑
|
||||
| How do the kidneys look in patients with ARPKD (autosomal recessive polycystic kidney disease? | Large smooth kidneys with narrow cysts perpendicular to the pasule and involving the collecting ducts
🗑
|
||||
| What percent of patients on dialysis develop cysts after 5 years | 75%
🗑
|
||||
| What disease results in translucent cysts on the surface of the cortex up to 10cm and is present in 50% of people >50 | Benign simple cystic disease
🗑
|
||||
| What is the most common cause of an abdominal mass in newborns | Multicysitc renal dysplasia
🗑
|
||||
| What are causes for Early Non-Function following Renal Transplantation | "Plumbing" problem, ATN, Acute Cellular rejection
🗑
|
||||
| When does Acute Cellular Rejection typically occur | usually within the first 3 months
🗑
|
||||
| How do you detect Acute Cellular Rejection | increasing creatinine
🗑
|
||||
| What findings support the diagnosis of Acute Antibody Mediated Rejection | Fluorescent antibodies to C4d and Donor Specific Antibodies
🗑
|
||||
| What is the most frequent cause of graft loss | Chronic Allograft Nephropathy
🗑
|
||||
| What Renal Diseases can be recurrent after transplant | Type II Membranoproliferative GN, Diabetic glomerulosclerosis, IgA nephropathy, Focal Segmental Glomerulosclerosis
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
UVAPATH3
Popular Medical sets