| Drug Name |
Uses |
MOA/Pharm |
Misc/Side Effects |
| Mechlorethamine (N-mustard) |
Hodgkins & NHL |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Vesiant activity = skin blistering |
| Melphalan (N-mustard) |
Breast & Ovarian cancer |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Vesicant |
| Chlorambucil (N-mustard) |
CLL (po) |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Vesicant |
| Cyclophosphamide (N-mustard) |
NHL, ALL, CLL, AML, CML |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Acrolein = Toxic metabolite --> hemorrhagic cystitis ( |
| Ifosfamide (N-mustard) |
same as Cyclophosphamide, but for pts w/ liver disfunction. Increased half-life = 7 hrs |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Acrolein = Toxic metabolite --> hemorrhagic cystitis ( |
| Busulfan |
CML |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
SE: Pulmonary fibrosis, hyperpimentation |
| Carmustine (Nitrosureas - IV) |
Brain Tumors (very lipophilic), Multiple Myloma |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
CNS toxicity, Lymphocytopenia, Thrombocytopenia |
| Lomustine (Nitrosureas - PO) |
Brain Tumors, Multiple Myloma |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
see carmustine |
| Streptozocin |
Pancreatic Islet Tumors |
Attaches carbon to another molecule --> Cross-linking, Mispairing, Depurination & Ring cleavage. |
Less BM toxicity, Renal & Hepato toxicity. |
| Dacarbazine |
Hodgkins, SLL, Melanoma, Glioblastoma |
MAO-I, also CYP activity |
HTN rxns --> avoid tyramines & sympathomimetics |
| Procarbazine |
Hodgkins, SLL, Melanoma, Glioblastoma |
see dacarbazine |
see dacarbazine |
| Cisplatin |
Bladder, Testicular, Ovarian & Small Cell Lung Cancer |
Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. |
Ototo & Renal toxicity, neuropathy, BM suppression |
| Oxaliplatin |
Bladder, Testicular, Ovarian & Small Cell Lung Cancer |
Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. |
Ototo & Renal Toxicity, neuropathy, BM suppression |
| Carboplatin |
Colorectal Cancer |
Platinum complex causes DNA cross-linking --> inhibit RNA & DNA Pol. |
BM suppression. Minor: ototo & renal toxicity and neuropathy |
5th Grade Science
