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PNS Receptors
Peripheral NS Receptors
| Receptor Subtype | Location | Response to receptor activatio |
|---|---|---|
| Cholinergic Receptor Subtypes | Nicotinic N, Nicotinic M, Muscarinic | (blank) |
| Nicotinic N | All autonomic NS ganglia and adrenal medulla | Stimulation of parasympathetic and sympathetic nerves and release of epinephrine from the adrenal medulla |
| Nicotinic M | Neuromuscular junction | Contraction of skeletal muscle |
| Muscarinic 1a/8 | Eye - the ciliary muscle | Contraction of the ciliary muscle focuses the lens for near vision |
| Muscarinic 1b/8 | Eye - the iris sphincter muscle | Contraction of the iris sphincter muscle causes miosis (decreased pupil diameter) |
| Muscarinic 2/8 | Heart | Decreased HR |
| Muscarinic 3a/8 | Lung - bronchi | Constriction of the bronchi |
| Muscarinic 3b/8 | Lung | Promotion of secretion |
| Muscarinic 4a/8 | Bladder - detrusor (smooth muscle of the bladder wall) | Contraction of detrusor increases bladder pressure |
| Muscarinic 4b/8 | Bladder - trigone and sphincter | Relaxation of trigone and sphincter allows urine to leave the bladder. |
| what causes voiding of the bladder? | Coordinated contraction of detrusor and relaxation of trigone and sphincter. - response to what reseptor? | Muscarinic |
| Muscarinic 5/8 | GI tract 1/4 | Salivation |
| Muscarinic 5/8 | GI tract 2/4 | Increased gastric secretions |
| Muscarinic 5/8 | GI tract 3/4 | Increased intestinal tone and motility |
| Muscarinic 5/8 | GI tract 4/4 | Defecation |
| Muscarinic 6/8 | Sweat glands | Generalized sweating |
| Muscarinic 7/8 | Sex organs | Erection |
| Muscarinic 8/8 | Blood vessels | Vasodilation |
| activation of nicotinic N (neuronal) receptors promotes (where, what)? | at all ganglia of the sympathetic and parasympathetic NS and also at the adrenal medulla | ganglionic transmission (from the former) and epinephrine release (from the latter) |
| Activation of muscarinic receptors (which are located on) 1-3/6 | the target organs of the parasympathetic NS (causes what?) | 1) incresed glandular secretions (from pulmonary, gastric,intestinal, and sweat glands). 2) contraction of the smooth muscle in the bronchi and GI tract; 3) slowing of HR; |
| Activation of muscarinic receptors (which are located on) 4-6/6 | the target organs of the parasympathetic NS (causes what?) | 4)contraction of the sphincter muscle of the iris (miosis); 5) contraction of the ciliary muscle of the eye (lens to focus for near vision); 6) voiding of the urinary bladder (contraction of the detrusor and relaxation of trigone and sphincter muscles) |
Created by:
AJJAD