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COMLEX 2
Teratogens
DRUG | EFFECT |
---|---|
EtOH | FAS (microcephaly, midfacial hypoplasia, MR, IUGR, cardiac defects) |
cocaine | bowel atresias, IUGR, microcephaly |
streptomycin | CN 8 damage/ototoxicity |
tetracycline | tooth discoloration, inhibition of bone growth, small limbs, syndactyly |
sulfonamides | kernicterus |
quinolones | cartilage damage |
isotretinoin | heart and great vessel defects, craniofascial dysmorphism, deafness |
iodide | congenital goiter, hypothyroidism, MR |
methotrexate | CNS malformations, craniofascial dysmorphism, IUGR |
DES | clear cell adenocarcinoma of vagina/cervix, genital tract abnl, cervical incompetence |
thalidomide | limb reduction, ear and nasal anomalies, cardiac and lung defects, pyloric or duodenal stenosis, GI atresia |
coumadin | stippling of bone epiphyses, IUGR, nasal hypoplasia, MR |
ACEIs | oligohydramnios, fetal renal damage |
lithium | ebstein's anomaly, other cardiac dzs |
carbamazepine | fingernail hypoplasia, IUGR, micorcephaly, NT defects |
phenytoin | nail hypoplasia, IUGR, MR, craniofascial dysmorphism, microcephaly |
valproic acid | NT defects, craniofacial and skeletal defects |
NSAIDs | NEC, constricting ductus ateriosis |
retinoic acid | CNS, craniofacial, CV effects |