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COMLEX 2

Teratogens

DRUGEFFECT
EtOH FAS (microcephaly, midfacial hypoplasia, MR, IUGR, cardiac defects)
cocaine bowel atresias, IUGR, microcephaly
streptomycin CN 8 damage/ototoxicity
tetracycline tooth discoloration, inhibition of bone growth, small limbs, syndactyly
sulfonamides kernicterus
quinolones cartilage damage
isotretinoin heart and great vessel defects, craniofascial dysmorphism, deafness
iodide congenital goiter, hypothyroidism, MR
methotrexate CNS malformations, craniofascial dysmorphism, IUGR
DES clear cell adenocarcinoma of vagina/cervix, genital tract abnl, cervical incompetence
thalidomide limb reduction, ear and nasal anomalies, cardiac and lung defects, pyloric or duodenal stenosis, GI atresia
coumadin stippling of bone epiphyses, IUGR, nasal hypoplasia, MR
ACEIs oligohydramnios, fetal renal damage
lithium ebstein's anomaly, other cardiac dzs
carbamazepine fingernail hypoplasia, IUGR, micorcephaly, NT defects
phenytoin nail hypoplasia, IUGR, MR, craniofascial dysmorphism, microcephaly
valproic acid NT defects, craniofacial and skeletal defects
NSAIDs NEC, constricting ductus ateriosis
retinoic acid CNS, craniofacial, CV effects
Created by: fl_sun80
 

 



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