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MICRO3
Innate immunity
| Question | Answer |
|---|---|
| PHAGOCYTOSIS | PHAGOCYTOSIS |
| What are the stages of phagocytosis? | Chemotaxis, adherence, ingestion, phagosome formation, intracellular killing, digestion, residual body formation, and discharge of waste |
| COMPLEMENT ACTIVATION OUTCOMES | See fig. 16.9 p. 491 |
| What are the results? | Inflammation, opsinization, cytolysis |
| What is involved in inflammation? what do each lead to? | C3a and C5a (signals for chemotaxis that attract WBC); release of histamine, which leads to swelling |
| What is invoved in opsinization? | C3b |
| What is opsinization? | Eat me signal |
| MULTISYSTEM DEFENSE MECHANISMS | ACTIVATORS OF INFLAMMATORY RESPONSE |
| What allows inflammatory response in bacteria? | LPS, Peptidoglycan, and Teichoic acids, CpG |
| What's an indicator for this in bacteria? Why? | DBL stranded RNA virus cause we dont' have it |
| What are the signs of inflammatory response? | Redness, heat, swelling, pain, loss of function |
| SEQUENCE OF INFLAMMATORY RESPONSE | SEE PAGE 488, FIG. 16.8 |
| Go through the steps: (TAke your time...) | Bacterial infection or injury, acute phase proteins increase, vasodilation, increased capillary permeability, leukocyte margination, lekocyte diapedesis, leukocytes destroy bacteria and host ells, fibrin deposition, abscess formation, healing (scar tissue |
| How long do neutrophils last ? | Short life-span |
| What is a cytokine | Interleukin |
| Increased capillary permeability leads to? | EDEMA (Swelling) |
| What does leukocyte diapedesis lead to? | Chemotaxis |
| What happens when leukocytes destroy bacteria nd host cell?; what kind of infection is this? | Pus; purulent infection |
| Fibrin deposition leads to? | Edema, bradykinin and prostagladin release |
| Antiviral dfense is due primarily to? | Interferons |
| What activates interferons? | Double stranded RNA; |
| What interferons are associated with viral passage from one cell to another? | Interferon Alpha and beta |
| NAME THE granulocytes? | Phils |
| What are agranulocytes? | Monocytes and lymphocytes |
| Results and steps of vasodilation and increased permeability of blood vessels/ | Release chemicals, blood clot, edema |
| Steps involved in migration and phagcytosis? | Migration, emigration, and diapedesis |
Created by:
talkglitter2486