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PHYS3

Regulation of Blood Pressure

QuestionAnswer
What is the major cardiovascular variable being regulated? Mean arterial blood pressure.
Why is this important to regulate? Because it is the driving force for blood flow to organs
What regulates mean arterial blood pressure? Stroke volume
How do you calculate MAP? Cardiac output x total peripheral resistance
What is TPR? Net resistance of all organs in body
BARORECEPTORS: What are the two kinds that exist? BARORECEPTORS; arterial and cardiopulmonary baroreceptors.
Where are the arterial baroreceptors located? Two carotid sinuses and aeortic arch.
What are arterial baroreceptors? Nerve endings that are sensitive to stretch due to changes in arterial blood pressure
What do they do with the change? Buffer changes in arterial blood pressure
What happens to wall of blood vessel and firing of AP when blood pressure is increased? Increased wall blood vessel --> Increase AP
What happens if you decrease pressure? Increase resistance and heart rate
What does the firing rates of arterial baroreceptors directly depend on? MAP and pulse pressure
What sort of feedback is associated with baroreceptors? negative feedback
CARDIOPULMONARY BARORECEPTORS? CARDIOPULMONARY BARORECEPTORS
Where are they located? Large systemic veins, pulmonary vessels, and the walls of the heart.
What is their function? Keep the brain informed of changes; Do the same as the other baroreceptors; They sense changes in stuff.
What sort of feedback don't they use? What kind of pressure do they measure? Don't use negative feedback. venous pressure
What does an increase in ABp lead to? Increase AP of arterial baroreceptors
What does afferent info do when stimulated? Goes up to cardiovascular center in medulla.
What do efferent nerves do when stimulated? Increase parasympathetic outflow and decrease sympathetic outflow.
The parasympathetic outflow goes to....? And the sympathetic outflow doesn't go to? Heart, arterioles, and veins
What is the result of the increase in arterial blood pressure? Decrease CO, TPR, and MAP
What is the arteriole baroreceptor reflex? Does the opposite of the above; i.e. decreases arterial blood pressure.
What is hte primary function of the baroreflex? Shoprt term regulation of arterial blood pressure
BLOOD VOLUME AND LONG-TERM REGULATION OF ARTERIAL PRESSURE LONG-TERM REGULATION OF ARTERIAL PRESSURE
Why can't baroreceptors set longo-term arterial pressure? Because they can adapt or reset to changes in arterial bp
Thus, what does regulate arterial pressure in the long-term? Volume, baby!
What happens to blood pressure when blood volume increases? BP goes up
Why does this happen? You increase venous return, E-D-V, SV, and C.O.
The increase in blood volume will then become what? Becuase of what? Will then become a decrease in blood volume b/c kidneys extrete salt and water
What sort of feedback is this? negative feedback loop
HEMORRHAGE AND HYPOTENSION HEMORRHAGE AND HYPOTENSION
Define Hypotension: What can cause hypotension? Low blood pressure; can be b/c of blood loss due to hemorhage.
What two mechanisms do we do to get over the hyipotension/ Reflex cardiovascular adjustments, and moving IF to capillaries
REFLEX CARDIOVASCULAR ADJUSTMENTS REFLEX CARDIO
What do we increase in this case? HR and TPR
What do we decrease (due to the bloo loss, not on purpose)? Stroke volume, Cardiac output, and MAP
MOVEMENT OF IF TO CAPILLARIES MOVE IF TO CAPS
What does this result in? (FINAL FINAL, imoprtant term)? Hemodilution
What is whole blood? Cells and plasma
What happens when you move IF to capillaries? ??????
What are you essentially doing in the capillary movment thing? Decrease Ventricular pressure and atrial pressure to decrease impact of hemorhage
What, other than hemorhage can cause hypotension? Loss of body fluids, strong emotion, vasodilation chemcials
What is shock? Low blood flow to tissues; damages them
UPRIGHT POSTURE UPRIGHT POSTURE
What is the effect of gravity upon blood? How? Reduce venous return by increasing vascular pressures in veins and capillaries in limbs
What happens when we stand up? Blood-->veins-->legs-->decrease stroke volume-->decrease cardiac output
What does the increased venous pressure cause? Distends veins and increases capilalry pressure-->increases filtration out of capillaries
When are these effects minimized? Skeletal muscle contraction in legs
EXCERCISE EXCERCISE
Why does CO increase in excercise? HR and stroke volume increases
What is redistribution? When the increase in cardiac output goes to vasodialating skeletal muscles and away from internal organs and nonactive skeleatl muscle
So how do we get blood to active muscles? Away from non-active muscles and ogans? Vasodialation; vasoconstriction
REGULATION REGULATION
What three things happen during excercise? Vasodilation, constriction, and increase HR
Why does vasodilation happen in excerciese? Active hyperemia
Why does vasoconstriction happen? SNS activity to internal organs and non-active muscles
Why does increase HR happen in excercise? Decrease parasympathetic and increased sympathetic activity
TRAINING TRAINING
What is the maximal oxygen consumption? What the only way to change it? Max oxygen use level; doesn't increase normally
Training: Increase max stroke volume and cardiac output by increasing oxygen consumption
HYPERTENSION HYPERTENSION
Why does hypertension happen? Increased TPR from increased arteriolar constriction
What is the most common hpertension type? What happens there? Why? Primary hypertension; caused by increased arteriolar constriction; we don't know why they increase
HEART FAILURE HEART FAILURE
HWhen does heart failure occur? Decreased contractility --> Not enough CO
What does an increase in diastolic volume do to systolic volume? Increases it
What does heart failure lead to? Makes kidneys retain fluid and increases capillary pressure
What does the capillary pressure increase lead to? edema and filtration
What does edema at the ankle mean? Right heart failure
What does pulmonary edema mean? Left ventricle failure
CORONARY ARTERY DISEASE CORONARY ARTERY DISEASE
Infarction: Complete coronary artery block
What can cause acute death from a heart attack? V-fib
Created by: talkglitter2486
 

 



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