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MICRO2
Antibacterial compounds
| Question | Answer |
|---|---|
| ANTIBIOTICS CLASSIFIED ACCORDING TO THEIR BACTERIAL TARGETS | CLASSIFIED ACCORDING TO ANTI-BACTERIAL TARGET |
| What are CELL WALL SYNTHESIS INHIBITORS | Penicillins and cephalosporins |
| PENCILLINUS: | PENCILLINUS |
| What is it? | The original Beta lactum structure penicillin G |
| What does Pen G. look like? | The beta lactum strucuture with a ring and methyl group |
| What are penicillinase resistant forms?> | change in structure to make penicillin active |
| What is an examle of one? And what doees it work on? | Methicillin (oxacillin)—Works on gram + orgs |
| What are some penicillinase inhibitors? | Clavulanic acid and augmentin |
| Which is used more often/ | Gluvanic acid b/c it is cheaper |
| Cephalosporins | CEPHALOSPORINS |
| Why do we need to use generations of ceophalosproins? | B/c bugs become resistant |
| How do cephalosporins work? | You don't kill the bacteria, you just create wall in cell |
| What cell type do they work against? | Gram + and negative |
| What is the final generation in which you can kill an infection/ | 4th generation |
| PROTEIN SYNTHESIS INHIBITORS | PROTEIN SYNTHESIS INHIBITORS |
| Why are Aminoglycosides good? | Active b/c bact ribosomes are different |
| What is an example of such a drug? On which organism does it work? | Streptomycin--effective on lots o' stuff |
| Chlorophenicol: | FIG. 20.10 ID |
| What does erythro do to the translation process? Where does it bind? | Erythro prevents move of ribosome along mRNA by bidning to the 30s portion. |
| FIG. 20.12 | We try to make them more active |
| Nucleic acid synthesis inhibitors: | SYNTHESIS INHIBITORS |
| What do they do? Example of one? | We make amino acid; Rifamycins |
| METABOLIC INHIBITORS | METABOLIC INHIBITORS |
| Whare are some of them/ | Sulfa drugs, and TMPSMZ |
| WHAT IS AN AWESOME DRUG REGARDING MIC AND ALL THAT? | Streptomycin, DUDE!! |
| What does penicilin, cephalosporins do? | Inhibit cell wall synthesis |
| What does streptomycin, erythromycin do? | Inhibit protein synthesis |
| What does rifampin, quinolones do? | inhibit replication |
| What does TMZ-SMP do? | Block metabolsim, little enzyme like thing |
| SMP is what kind of inhibitor? Top or bottom of sequence? | competitive; top of sequence |
| TMP is what kind of inhibitor? Top or bottom? | competitve one (bottom os sequence) |
| In what three ways can a bacteria increase its resitance to a drug? | !) Enzymatic destruction of the drug 2) Lack of entry into cell 3) Change drug target |
| What are the two types of anti-fungal drugs we need to know? | Cotrimazole, microtonozole |
Created by:
talkglitter2486