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Bordetella/Legionela

MedMicro 2006 UTHSCmed

QuestionAnswer
Bordetella pertussis Shape small coccobacillus
Bordetella pertussis Aerobicity Strict aerobe
Bordetella pertussis Oxidase +/-? Osicase +
Bordetella pertussis fermenter NON-fermenting
Bordetella pertussis Motility NON-motile
Bordetella pertussis virulence factors Adhesins, pertussis toxin: ADP-ribosylate, INC. cAMP; coordinated transcription of pathogenic genes
Bordetella pertussis Pathophysiology Broplet nuclei; colonizes ciliated ceells, ciliostatsis: noninvasive; infects upper respiratory tract
Bordetella pertussis Diseases Whooping cough (contagious in catarrhal stage)
Bordetella pertussis Specimen Nasopharyngeal swab
Bordetella pertussis Lab Diagnosis Chocolate agar, serology, immunofluorescence
Bordetella pertussis Treatment Erythromycin (catarrhal or prophylactically), supportive treatment later
Bordetella pertussis Prevention/Control DPaT vaccine (acellular)
Bordetella pertussis NOTES: lymphocytosis; Incubation, catarrhal, paroxysmal, convalescent stages
B. parapertussis & bronchiseptica Shape small coccobacillus
B. parapertussis & bronchiseptica Aerobicity strict aerobe
B. parapertussis diseases Mild pertussis
B. bronchiseptica diseases respiratory disease (rare in humans)
Legionella pneumophila Shape Pleomorph: bacillus to coccobacillus
Legionella pneumophila Aerobicity Aerobic
Legionella pneumophila Catalase +/-? Catalase +
Legionella pneumophila fermeter NON-fermenting
Legionella pneumophila motility Motile
Legionella pneumophila temperature 0-63 C
Legionella pneumophila cirulence factors Survive inside macrophages; proteolytic enzymes
Legionella pneumophila pathophysiology Aerosolization, infects lower respiratory tract, causes intra-aveolar exudate of PMN's and macrophages
Legionella pneumophila reservoir Water
Legionella pneumophila diseases Legionnaire's disease (pneumonia, adnormal chest X-ray, bacteremia), Pontiac fever (normal chest x-ray)
Legionella pneumophila lab diagnosis fastidious: requires L-cys for growth; gram stain, DFA, ELISA
Legionella pneumophila treatment Axithromycin or levofloxacin (severe), erythromycin or tet (milder), no treatment for Pontiac fever (self-limiting)
Legionella pneumophila prevention/control Hyperchlorination/treatment of water
Legionella pneumophila NOTES: facultative intracellular pathogen, Legionnaire's disease has high mortality
Legionella pneumophila is a ubiquitous aquatic saprophtyte
slender, Gram - aerobic bacilli Legionella pneumophila
The two manifestations of Legionella pneumophila are Legionnaire's disease and Pontiac fever
2nd or 3rd most common cause of pneumonia Legionella pneumophila
Bordetella stages:catarrhal Resembles common cold; Purfuse mucoid rhinorrhea; malaise , fever, anorexia, sneezing. Most infectious stage
Bordetella stages: paroxysmal convulsive coughing (w/whooping sound) for 2-4 wks up to 50 times a day often followed by vomitting
Bordetella stages: convalescent gradual decrease in coughing and other symptoms. secondary complications: pneumonia, seizures, encephalopathy
Incubation period is 7 - 10 days Whooping cough
Created by: Garzilla
 

 



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