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Zoonotic Diseases

MedMicro 2006 UTHSCmed

QuestionAnswer
Yersinia pestis shape Bacillus
Yersinia pestis Aerobicity facultative anaerobe
Yersinia pestis fermenter? YES it is a fermenter
Yersinia pestis motility NON-motile
Yersinia pestis virulence factors YOP proteins, capsule
Yersinia pestispathophysiology Skin to bubo to bacteremia, lungs=pneumonic; septicemic
Yersinia pestis reservoir Rats through fleas
Yersinia pestis diseases Bubonic and pneumonic plague
Yersinia pestis specimen Bubo aspirate, blood, sputum
Yersinia pestis lad diagnosis Immunoflourescence
Yersinia pestis treatment streptomycin, tetracycline, doxycline
Yersinia pestis prevention and control rat control, pesticide, vaccine for high risk
Yersinia pestis Kille 1/4 of europe, subcutaneous hemmorrhage="black death", facultative intracellular pathogen and sylvanic(rural) vs. urban (city) rodents
Francisella tularensis Shape Coccobacillus
Francisella tularensis aerobicity Facultative anaerobe
Francisella tularensis oxidase +/- ? Oxidase +
Francisella tularensis fermenter? NO
Francisella tularensis motility NON-motile
Francisella tularensis virulence factors penetrates unbroken skin; capsule, LPS (not very active)
Francisella tularensis Pathophysiology skin to lymphatics to granuloma or pneumonia; ulcer at bite site; typhoid-like fever
Francisella tularensis reservoir rodents and ticks or deer flies
Francisella tularensis specimen sputum or exudate; skin test (rare)
Francisella tularensis diseases tularemia (rabbit fever); ulceroglandular (bite); typhoidal (bad meat, rare), or pulmonary (rare)
Francisella tularensis lab diagnosis serology
Francisella tularensis treatment Streptomycin
Francisella tularensis prevention/control gloves with animals, remove ticks, vaccine for high-risk
Francisella tularensis NOTES: survives inside macrophages; seasonal incidence
Francisella tularensis NOTES: facultative intracellular pathogen; typhoidal and pulmonary have high mortality
Brucella (melitensis, suis, abortus, canis) shape Coccobacillus
Brucella (melitensis, suis, abortus, canis) aerobicity facultative anaerobe
Brucella (melitensis, suis, abortus, canis) oxidase +/- ? Oxidase +
Brucella (melitensis, suis, abortus, canis) fermenter? NO
Brucella (melitensis, suis, abortus, canis) motility NON-motile
Brucella (melitensis, suis, abortus, canis) virulence factors LPS endotoxin
Brucella (melitensis, suis, abortus, canis) reservoir goats and sheep (melitensis), suis (pigs), abortus (cattle)
Brucella (melitensis, suis, abortus, canis) diseases brucellosis (undulating fever): acute (enteric illness), localized (in women), chronic, relapsing, or strain 19 (calf vaccine)
Brucella (melitensis, suis, abortus, canis) specimen blood, bone marrow, incubate for 6 weeks
Brucella (melitensis, suis, abortus, canis) lab diagnosis serology; culture on blood agar (slow, fastidious)
Brucella (melitensis, suis, abortus, canis) treatment tetracycline + streptomycin for 3 weeks
Brucella (melitensis, suis, abortus, canis) prevention/control no human vaccine in US; vaccinate cattle; minimize occupational exposure, pasteurize dairy products
Brucella (melitensis, suis, abortus, canis) NOTES: Urease + , Facultative intracellular pathogen
Pneumonic Plague very contagious and rapidly fatal.
Pneumonic plague can occur from: metastic for bubo, Inhalation from infected person, direct inoculation of the lungs
Septicemic Plague High mortality
Septicemic Plague occurs by: Organisms inoculated directly into blood by flea.
Francisella tularensis (enteric) typhi-like fever Hallmark feature is temp/heart rate dissociation
Francisella tularensis pulmonary hallmark frothy bloody sputum like in pnuemonic plague
Created by: Garzilla
 

 



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