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Bone Marrow

UCI SOM Smith

QuestionAnswer
Hemopoietic tissue bone marrow (myeloid tissue) and lymphoid tissue
Hemopoiesis week 2-mesoblastic phase; month 2-hepato-splenic phase; end of 2nd trimester- myeloid phase starts and continues through life
When do leukocytes appear after conception week 8
Stroma of marrow 3D network of reticular/adventitial cells and reticular fibers in bone marrow
Parenchyma of marrow divided into hematopoietic compartments responsible for the synthesis of erythrocytes and leukocytes
Hematopoietic cells B and T lymphocytes, erythrocyte, megakaryocyte, monocyte, neutrophilic granulocyte, eosinophilic granulocyte, basophilic granulocyte
Erythropoiesis 5 steps proerythroblast, basophilic erythroblast, polychromatophilic erythroblast, orthochromatophilic erythroblast, reticulocyte
Proerythroblast large, loose lacey chromatin, visible nucleoli, basophilic cytoplasm
Basophilic erythroblast onset of Hb synthesis, strongly basophilic cytplasm, condensed nucleus, no nucleoli
Polychromatophilic erythroblast cytoplasm filled with Hb, polyribosomes begin to decrease, final stage at which mitosis can occur
Orthochromatophilic erythroblast cytoplasm filled with Hb, few polyribosomes, condensed nucleus, normoblast-late orthochromatophilic erythroblast
Reticulocyte anucleate, most immature form released into circulating blood
Granulopoiesis 6 steps myeloblast, promyelocyte, myelocyte, metamyelocyte, bend form, segmented neutrophil
Monopoiesis (3 stages) monoblast (like a myeloblast), promonocyte (large, basophilic cytoplasm, lacy chromatin, slightly indented nucleus, last mitotic stage) and monocyte,
Lymphopoiesis mostly occurs in thymus and peripheral lymphoid tissue but all lymphocyte progenitors come from bone marrow; lymphoblast -> prolymphocyte (smaller, condensed chromatin, lack surface antigens, migrate to lymphoid tissue)
Chronic leukemia slow, proliferating cells are partly or completely differentiated
Acute leukemia rapid progression, proliferating cells are undifferentiated precursur cells
Thrombocytopenia reduction in platelet count; leukemia, metastatic cancer, chemotherapeutic drugs
Petichiea purple pin pricks (thrombocytopenia purpura)
Echymoses large breaks/bruises (thrombocytopenia purpura)
Created by: droid
 

 



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