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N/V Therapeutics
| Question | Answer |
|---|---|
| What drugs cause N through gastric statis (3): | TCA (amitriptaline); anticholinergics; phenothiazines |
| Meds that cause N: | DA agonists, opioids, digoxin, nicotine, chemo (2 MOAs-Seratonin acute and nonseratonin delayed) |
| Metabolic causes of N: | uremia, hypoxemia, hyPERcalcemia, DKA, prego, toxin |
| Receptors involved in CTZ: | dopamine, seratonin, muscarinic, and histaminic |
| Receptors involved in labyrinths: | Muscarinic, histaminic |
| Labrinths is what kind of N? | Due to motion sickness |
| Peripheral afferents stimuli include? | any direct to GI irritation (Nsaids, ASA, local radiation, iron pills, Abx, toxin) |
| Receptor involved in peripheral afferents? | seratonin |
| Cerebral cortex has what stimuli? | odors and taste |
| Scopalamine: indication; MOA; Counsel: ADR | prevent motion sickness and salivation; anticholinergic; apply 4H before wanted effect to 72Hl and causes DRYNESS |
| List the antihistamine drugs: | diphenhydramine; dimehydrinate, meclizine, promethazine, trimethobenzamide |
| PO formulations of AH are for? | motion sickness |
| IV formulations of AH are for? | generalized N |
| DOC AH is? | Promethazine |
| ADR? | Burning with peripheral admin and NOT if <2y.o |
| Dopamine antagonists are? | Phenothiazines, butyrphenones (haloperidol) benzamides (metoclopramide) |
| Indication of metocloprimide? | PCNV prevention |
| advantage of phenothiazine? | less sedating |
| Advantage of haloperidol? | Long DOA |
| Advantage of metocloprimade? | HD - PCNV prevention |
| ADR of dopamine receptor antagonists? | EPS, dyskinesia (muscle tighness) |
| Tx with? | Diphenhydramine |
| What are the seratonin blockesr? | *setron |
| Best use? | Cancer CINV/PCNV |
| Best to use for delayed PCNV? | Ganisetron patch applied 24H before |
| Longest DOA? | Palonosetron |
| Advantage? | No EPS |
| ADR? | H/A, LFT changes |
| Corticosteroids DOC? | Dexamethasone |
| Best indication? | Combo with seratonin antag and metocloprimide and for edema |
| What are the BZD? | Lorazepam |
| Indication? | Anticipatory N in COMBO with something. NEVER USE ALONE. |
| Prittinant ADR? | Never with CYP drug; NK1 antagonists for prevention of CINV/PCNV |
| Cannaboids example? | Nabilone (expensiive and last resort CINV) |
| Compounded regimens, give them both? | ABH (ativan, benadrl, haldol)and RBD (dexameth, reglan, benadryl) |
| Prego first line tx? | Vit B6 |
| If that didn't work? | Add doxylamine (or benadryl) (AH) |
| If that didn't work? | Add promethazine (still AH) or dimenhydrinate |
| If dehydrated? | Fluid replace; add AH-->methylpred or ondansetron (last) |
| If NOT dehydrated? | Add meto or prometh |
Created by:
talkglitter2486