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pharm ch. 15
Psychotherapuetic agents
| drug or term | definition: class, MOA, SE, |
|---|---|
| chlorpomazine (Thorazine) | (blank) |
| haloperidol (Haldol) | (blank) |
| chlorpomazine (Thorazine) | antipsychotic older med- blocks dopamine |
| haloperidol (Haldol) | antipsychotic--- older med -- blocks dopamine |
| clozapine (Clozaril) | antipsychotic -- works on serotinon and dopamine |
| resperidone (Risperdal) | antipsychotic -- works on serotinon and dopamine |
| olanzapine (Zyprexa) | antipsychotic -- works on serotinon and dopamine |
| ziprasidone (Geodon) | antipsychotic -- works on serotinon and dopamine |
| arirpiprazole (Abilify) | antipsychotic -- works on serotinon and dopamine |
| older antipsycholitcs SE | momement disorders known as EPS (Extrapyrmaidal side effects) |
| SE of antipsychotics-- | photsensity, sedation and orthostatic hypotension, anticholinergec effects, rare, dangerous SE-- nerulopetic malginant syndrome |
| clozapine (Clozaril) SE | agranulocytosis --An acute disease marked by high fever and a sharp drop in circulating granular white blood cells. |
| SSRI | Inhibition of serotinon reuptake - also weak effects of norepiniphine and dopamin uptake . 2nd and 3rd generation less selective and have activity on brain seratonin as well as norepinephrine receptors |
| older antiphsychotic work best on.... | work best on "positive" symptoms such as hallucinations, delustions |
| newer antiphsychotics work best on.... | work on "negative or deficit" sx such as apathy, social withdrawal |
| fluoxetine (Prozac) | SSRI antidepressent |
| Sertaline (Zoloft) | SSRI antidepressent |
| paroxetine (Paxil) | SSRI antidpressent |
| citalopram (Celexa) | SSRI antidpressent |
| escitaloporam oxalate (Lexapro) | SSRI antidpressent |
| TCAs (tricyclics) | inhibit the uptake of seratonine and norepinephrine at nerve endings =these nuerotransmitters accumulate at nerve ending |
| aminotriptyline (Elavil) | TCAs |
| MAOI | inhibits the breaking down of neurotransmitters which alleviates symptoms of depression = Any of a class of antidepressant drugs that block the action of monoamine oxidase in the brain, thereby allowing the accumulation of monoamines such as norepinephri |
| MAOI SE | tryamine can cause adverse food allergies |
| phenelizine (nardil) | MAOI |
| buporopion (Wellbutrin or Zyban) | 2nd gen. of modles effect on blockagedof dopamine -- smoking cessation |
| vemlafaxine (Effexor) | meds that regulate serotonin and norepinephrine |
| duloxetine (Cymbalta) | regualte serotonin and norepinephrine |
| Antipressants major uses (SSRI, MAOI, & other ) | majordepression, obsessive compulsive disorder (OCD), panic disorders (MAOIs sometimes used), PMS, chemical dpedency with depression (dual dx), seasonal affective disorder |
| Prozac admin info | give in am and po |
| SSRI SE | insominia, wt gain, and sexual dysfunction |
| TCA SE | tendency to cause fatal cardiac dysrhythmias following overdose. |
| Newer generation antidepressant SE | headache, dizziness, tremor, nervousness, insomnica, fatigue, nausea, diarrhea, constipation,dry mouth, weithgt loss/gain, sweating, sexu dysfunction |
| bupropion side effects | associated with reduced sexua side effects. |
| antidepressent combination SE | serotonin sydrome (serotonigergic activity) |
| TCA's contraindication | should not be used within 2 wks of MAOIs (hypotension and tachycardia) |
| SSRI contraindication | should not be used within 2-5 wks of MAOIs (serotinin syndrom could be fatoal withhyperthermia, rigitidy, fluctuation VS, delirium, coma) |
| MOAIs contraindication | hypertensive crisisif not on low tyramine diet |
| lithium carbonate (lithodbid) | mood stabilizer |
| carbamazepine (Tegretol) | mood stabilizer |
| vlaproic acid (Depakote) | mood stabilizer |
| gabapentin (Neurontin) | mood stablizer |
| lithium carbonate (lithobid ) MOA | exact MOA unknown it is anutrally occuring salt - alters neuronal socium transport |
| carbamenazepine (Tegretol) MOA | reduces post -tetanic potentiation, decreasing seizure to spread; similiar to TCAs |
| lithium carbonate (lithobid) indicated for | treatment of choice of mania; prevent recurrent suicidal depression |
| lithium routes | PO |
| lithium ranges | .8-1.2 or aoun 1.0 |
| lithium side effects | Lethargy, slurred speech, muscle weakness, fine hand tremor |
| lithium toxicity | levels above 1.5 or 2.0possible causes of toxicity - lfuid and salt intake important |
| chlordiazapoxide (Librium) class | antianziety meds - benzodiazepine |
| Lorazepam (Ativan ) class | antianziety meds - benzodiazepine |
| chlordiazapoxide (Librium) MOA | potentiate GABA |
| Lorazepam (Ativan ) MOA | potentiate GABA |
Created by:
mashechka