| Question |
Answer |
| All Hg |
To Hg++ (inorganic), half life = 1-2 monthes (long). |
| Hg0 |
ELEMENTAL, volatile (thermometers), inhaled, kidneys, cross BBB, INFLAMM in lungs (interstit pneumonia, corrosive bronch), thyroid, hematopo, ging, saliv, CNS (mem loss, excitable (erethism), depress, hallucin, thermoreg, dec fine motor). |
| Hg++ |
INORGANIC, chloralkali, paper industry, GI absorbtion (10%), kidneys, CORROSIVE, GI bleed, necrosis, circulatory shock, renal railure, immunologic glom inj (protein), target kidneys and neuropathy. |
| Methyl Hg |
ORGANIC, from Inorganic + water bugs (Japan fish, Iran grain), GI absorb 90%, brain, neurotox (periph, central), paral, atax, numb, neuranest (weak, tired, no concen), vision, hearing, spast, tremor, coma, death, terato (lots of proteins / mech bind DNA) |
| Treatment Hg |
Case of dimethyl poisoning. Hemodialysis, chelator, cysteine, penicillinase, britis, dimercaprol <-> antilewisite (BAL), nucleophile + Hg++ -> pulls out. |
| Pb++ |
Soil, water, paint, clothes, shoes, chinese toys, sources dec. Abosorb : inhale particles, eat (children absorb 40% adults 10%). Distribution : 1st high blood flow(liver, kidneys), blood (99% bound to Hb), then bone (high affinity with low blood flow). |
| Pb++ Elimination |
Kidneys (slow) and some minor. Half-life = 1-2 monthes (20-30 years from bone). Acute SEs (rare) : mouth, nauesea, GI, vommit, shock, nerves, hemolysis, kidneys (oliguria), death (high dose), cross to placenta. Chronic : CNS spawn, GI adults. |
| Chronic Pb++ Indepth |
GI, NMS (Pb palsy) -> nerves, wrist dropw, CNS, taste metals, dizzy, etc..., Coma > 60 = toxic cause metal retardation, > 10 spawn = subtle IQ issues. Hematologic (spawn esp) = porphyrin synthesis, renal (precipitates), other = lead line, death rare. |
| Pb Diagnosis |
BLL = recent exposure (30-75), chelate with EDTA to pull out of tissues. |
| Pb Treatments |
Treatment : support, seizures, fluids, edema, chelators like succimer. Organic : Tetraethyl in gas, lipid soluble, CNS. |
| Iron |
FeSO4 tablets (spawn eat), Iron OD (hemochromotosis, blood transfusion). Effects : vomit, GI ulcers, shock, metabolic acidosis, liver injury, renal failure. Mechanism : complex, ROS -> lipid perox -> organ damage. Antidotes : chelator (deferoxamine). |
BIOL3326 Forms
