| Question |
Answer |
| What is the kidneys function? |
1)excretion of metabolic waste products and foreigen chemicals 2)regulation of water,electrolyte,osmolality, electrolyte concentration 3)reg. acid-base balance 4)reg. arterial pressure 5)hormone sec. 6)gluconeogenesis |
| What kind of waste products? |
Urea, creatine, uric acid, bilirubin, metabolic wastes, things not needed by body and toxins. |
| Describe the renal blood supply. |
Renal arterie-> |
| What is a nephron? |
Kidneys functional unit includes glomerule, bowmanscapsel and tubule |
| Descibe the different between cortical and juxtamedullary nephorns! |
Cortical<-cortex, Juxtamedullary<-medulla - vasa recta (supplies medulla with nutrition)- concentrates the urine |
| Urinary formation is a result of? |
Glomerule filtration, tubular reabsorbtion and tubuar secretion. |
| Why is secretion important? |
It determents the amount of K and H excreted in urine. |
| Why does our body filtrate a large amount of fluid and then reabsors it? |
1) to be able to remove wastes fast 2)high GFR allow all fluid to be filtred and processed many time per day (60X) |
| What does the filtrated fluid contain? |
Its has the same organic and solute concentration as plasma but absent of protien. |
| What is not filtered? |
Ca and fatty acids and large particles. |
| How many precent of renal plasma is filtered? |
20% |
| What is the filtration fraction? |
Ff=Gfr/renal plasma flow (0,2=120/600) |
| What does increased Ff lead to? |
(blank) |
| What happens when glomerular cap hydrostatic pressure changes? |
increased HP->Inc. GFR | decreased HP->decreased GFR |
| What is glomerular hydrostatic pressure determined by? |
1)Arterial pressure 2)aff. arteriol resistens 3) efferent arteriol resistens |
| What happens when you change things that determins hydrostatic pressure? |
incr. arteriol pressure->incr. GFR | incr. affer resistens->decr. GFR | incr. efferent resistens->incr.GFR (But to much->decr. GFR) |
| Describe the filtration barrier! |
1) endothelial, fenestrated 2)basmentmembrane 3)podocytes |
| Explain why negatibly charged molecules have difficulty passing the filtration barrier! |
Because of the negative charge barrier in basment and podocytes. |
| What determents GFR? |
GFR=Kf X (Pg-Pb-Cg+Cb) (125=12,5x(60-18-32+10)) |
| Increased bowman's capsule hydrostatic pressure leads to? |
Stones->increased pressure-->decreased GFR->damages kidney |
| Increased glomerular capillary colloid osmotic pressure leads to? |
Decreased GFR, (without this force all plasma would be filtrated) |
| Why does the glomerular capillary colloid osmotic preussure rise from afferent to efferent arteriol? |
Because of filtration which leads to incr. glomerular colloid osmotic pressure (more protiens then before) |
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