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Neuropath final

Seizure disorders

QuestionAnswer
Drugs that can cause Seizures: Prenatal factors cocaine, heroine, drug withdrawl
Drugs that can cause Seizures: Abs: PCN, isoniazid(dyfrazid); antidepress: amiltriptyline, doxepin, OD; antipsychotic: haldol, chrlopromazine, Asthma: aminiphylline; LI, local anesthetics: lidocaine, procaine
Prenatal (22wks-1 month after birth causes of seizures Hypoglycemia: <30 in first 72, <40 after 72, diabetic mothers: even higher; Hypocalcemia: reduce ap threshold, <7, assoc w/ hypomag, Digeorge's sydnrome: no thymus no PTH(inc Ca), GBS, NKC: 25%; excessive molding delivery: temporal lobe damage
Manifests of abscence (petit mal) child:2-10; ansentness/stare, brief lasting, may have upward eye move, remission in 70-80%, poor prog if >15(progress to GM) normal Iq and development
West syndrome Triad: spasm, hyperarrhytmia, abn interictal high amplitude waves and a background of irregular spikes on EEG, mental retard, onset 3-6 months, spasms stop 5, infants benf forward and stiffen body and limbs(jack knife, occures in clusters(1-200spasms)
Complex partial/temporal lobe seizures POS; albe to inter w/ envir altho exhib inaprop behavior, remove irrit area, everyone diff, manifests:preictal: autonomic sens, cog sens(deja), affect state, automatisms(hand mot, utter), ictal: brief, disorg, unable to speak, postictal: confusion
Seizures of under 45 idiopathic(45%), CNS infect(17.5%), EtOH(15%)
Sezires of over 45 infarct(37.9%), idiopathic(15.5%), CNS tumor(12%)
Seizures in birth to 3 days Hyoxema/ischemia, instrcranial infection, metabolic(hypoglycemia, early onset hypocalcemia, drug withdrawl, cerebral vascular(trauma related), benign familial neonatal seizrues
Sezires in over 3 day old Infection GBS, Brain malformation, metabolic late onset hypocalcemia, inborn errors of metab, pyridoxine (vit b6) def(myoclonic spasm)
Seizure disorder in preggers 2x likely have multiple births, c section, have eclampsia, preggers lowers threshold, fetal hydantoin syndrome
Created by: bmg4
 

 



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