| Question |
Answer |
| What are the most effective nonspecific antidiarrheal drugs? |
Opiates and Opiate Derivatives |
| Name two opiate/opiate derivative antidiarrheals |
Loperamide (imodium) and diphenoxylate with atropine (Lomotil) |
| Would you give antidiarrheal drugs with:Antibiotic associated colitis |
No |
| Would you give antidiarrheal drugs with:Relatively severe diarrhea in young children and older adults |
Yes |
| Would you give antidiarrheal drugs with:HIV/AIDs associated diarrhea |
No |
| Would you give antidiarrheal drugs with:Diarrhea caused by toxic materials |
No |
| Would you give antidiarrheal drugs with: Microorganisms that penetrate the intestinal mucosa |
No |
| Would you give antidiarrheal drugs with:Chronic inflammatory bowel disease |
Yes |
| Would you give antidiarrheal drugs with:severe or prolonged diarrhea for more than 2 days |
Yes |
| What is the main adverse effect of antidiarrheal medications |
Constipation |
| What type of patient would Alosetron (Lotronex) be used for? |
A woman with severe diarrhea-predominant irritable bowel syndrome |
| What are the potential serious adverse effects of Alosetron (Lotronex)? |
GI obstruction, perforation, hemorrhage, ischemic colitis. |