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Regeneration GFs

Growth Factors & cytokins involved in reegeneration & wound healing - POD test 3

QuestionAnswer
EGF stands for Epidermal Growth Factor
Source of EGF Platelets, macrophages, saliva, urine, milk, plasma
Functions of EGF Mitogenic to epithelial cells and fibroblasts in vitro
This growth factor is widely distributed in tissue secretion and fluids EGF (Epidermal Growth Factor)
TGF-alpha stands for Transforming growth factor alpha
Source of TGF-alpha Macrophages, T lymphocytes, keratinocytes, and many tissues
Functions of TGF-alpha Stimulates replication of hepatocytes and certain epithelial cells
HGF stands for Hepatocyte growth factor/scatter factor
Source of HGF Mesenchymal cells
Functions of HGF Enhance proliferation of epithelial and endothelial cells, and of hepatocytes; increases cell motility
VEGF stands for Vascular endothelial cell growth factor
Source of VEGF Mesenchymal cells
Functions of VEGF Increases vascular permeability; mitogenic for endothelial cells
PDFG stands for Platelet-derived growth factor
Source of PDGF Stored in platelet alpha-granules and released upon platelet activation
PDGF is produced by activated macrophages, endothelial cells, smooth muscle and tumor cells
PDFG causes migration and proliferation of fibroblasts, smooth muscle cells and monocytes.
FGF stands for Fibroblast Growth Factors
FGF causes migration of macrophages, fibroblast and endothelial cells in damaged tissue, and migration of epithelium to form new epidermis
TGF-beta stands for Transforming growth factor beta
TGF-beta is produced by platelets, endothelial cells, lymphocytes and macrophages
Function of TGF-beta Stimulate fibroblast chemotaxis; stimulates production of collagen and fibronectin; decreases collagen degradation
This peptide is a growth INHIBITORY factor in epithelial cells and fibroblasts and smooth muscle cells at high concentrations, and STIMULATORY factor in fibroblasts and smooth muscle cells at low concentrations. TGF-beta
This growth factor is mitogenic to epithelial cells and fibroblasts in vitro. EGF
This growth factor causes hepatic cell division in vivo. EGF
This growth factor is stored in platelet a-granules and released upon platelet activation. PDGF
This growth factor is produced by activated macrophages, endothelial cells, smooth muscle and tumor cells. PDGF
This growth factor causes migration and proliferation of fibroblasts, smooth muscle cells and monocytes PDGF
This growth factor is involved in angiogenesis and wound repair. FGF
This growth factor causes migration of macrophages, fibroblasts and endothelial cells in damaged tissue. FGF
This growth factor causes migration of epithelium to form new epidermis during wound repair. FGF
These two growth factors are responsible for angiogenesis. FGF and VEGF
This growth factor is produced by platelets, endothelial cells, lymphocytes and macrophages TGF-beta
This growth factor stimulates fibroblast chemotaxis. TGF-beta
This growth factor stimulates production of collagen and fibronectin. TGF-beta
This growth factor decreases collagen degradation. TGF-beta
These three factors favor fibrogenesis and are functions of TGF-beta. Fibroblast chemotaxis, production of collagen and fibronectin, decrease of collagen degradation.
High concentrations of TGF-beta have what kind of effect in fibroblasts and smooth muscle cells? Growth inhibition
Low concentrations of TGF-beta have what kind of effect in fibroblasts and smooth muscle cells? Growth stimulation
Created by: P1StudyStack
 

 



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