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WVSOM -- Genetics

WVSOM -- Cell Cycle control

QuestionAnswer
What are the two kinds of cyclins? G1 and G2
What is CDK cyclic dependant kinase
Whant does CDK kinase activity increase? When G1 and G2 levels are higher
What special name goes with the cdk G2 cyclins? cdc2
What do the MPF complxes do? phosphorylate nuclear lamins, H1 Histone, MAP kinase and cdc25
What is MPF It is teh complex of the cdc2 and the G2 cyclin cofactors together
What does MPF allow between complexes? cross talk
What are teh checkpoints? Other pathways that control the pathway of the cdk pathway within thecycle
Restriction point Middle of G1 and allows the cell to progress to S phase
Where is teh check point to check completion of DNA replication? End of S
Tumor suppression genes During S phase. Checks for damaged DNA; If active it prevents the cell from progression.
Kinetochore-mitotic spindle associated checkpoint During Mitosis and checks to make sure everythign is connected to the spindles
why are checkpoints important? without them cancer occurs
Why do cancers occur? checkpoints break down
Multi-kit hypothesis One mutation cannot cause cancer
What are most common cancer mutaion? in p53 and the blastoma (tumor suppressor gene)
Ungel genes when over expressed cause cancer; will cause the cell to keep producing
How does retinoblastoma get phosphorylated to release E2F? the GI cyclin/cdk complex phosphoyrlates the RB until it releases E2F
What is E2F? a transcription factor that lead to S phase
DNA Damage ocogenes lead to what enzyme? p53
Where can p53 lead to if correction is not made? apoptosis
Where can p53 lead to? apoptosis or p21
Created by: tjamrose
 

 



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