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Pharm
Small Class Antibiotics
| Question | Answer |
|---|---|
| MOA, Aminoglycosides | Inhibit Protein Synthesis |
| Two Aminoglycosides | Gentamycin, Tobramycin |
| Use, aminoglycoside | Gram negatives, in combo with other drugs. Rarely used alone except UTIs. |
| MOA, Macrolides | Inhibit protein synthesis by binding to 50S |
| Name two Macrolides | Clarithromycin, Azithromycin |
| What can a single dose of Azithromycin be used for? | Chlamydia |
| What are Marcolides excellent against? | Atypicals |
| MOA, Ketolides | Inhibit protein synthesis by binding to 50S. |
| Name a Ketolide. | Teltihromycin/Ketek. |
| MOA, Clindamycin | Inhibit protein wall synthesis by binding to 50S. |
| What is a drawback of Clindamycin? | Worst offender of C. Diff Colitis. |
| What is Clindamycin typically used for? | Gram positives, some anaerobes. |
| What is a strength of Clindamycin | Can do community acquired MRSA. |
| What is Metronidazole used for (general and specific)? | Anaerobes and parasites: C. Diff. |
| What are the tetracylcines used against? | Rickettsia and atypical pathogens. |
| Name a tetracylcine. | Doxycycline (Vibramycin) |
| Which antibiotic stains kids teeth? | Tetracyclines |
| What should Septra/Bactrim be used for? | Gram negative urinary pathogens, protozoa, PCP |
| What is Vancomycin used for? | MRSA, very strong against gram positives. No gram negative. |
| Describe Daptomycin. | Like Vanc, but covers more. |
| What should Daptomycin NOT be used for? | Pneumonias/CNS. |
| Name an oxazolidinone? | Linezolid |
| What was oxazolidinone developed to do? | Treat resistant gram positive stuff, MRSA, vanc resistant staph |
| What can the Oxazolidinones cause? | Thrombocytopenia |