| Question |
Answer |
| Association for tumor marker: PSA |
Screening for Prostatic Carcinoma |
| Association for tumor marker: CEA |
-Carcinoembryonic antigen. -In ~70% of colorrectal and pancreatic cancers -Also produced by gastric and breast carcinomas -Very nonspecific |
| Association for tumor marker: alpha-fetoprotein |
-Hepatocellular carcinomas -Nonseminomatous germ cell tumors of the testis (eg yolk sac tumor) |
| Association for tumor marker: beta-hCG |
-Hydatidiform moles -Choriocarcinomas -Gestational trophoblastic tumors |
| Association for tumor marker: CA-125 |
Ovarian malignant epithelial tumors |
| Association for tumor marker: S-100 |
-Melanoma -Neural tumors -Astrocytomas |
| Association for tumor marker: Alkaline phosphatase |
-Metastases to bone -Obstructive biliary disease -Paget's disease of bone |
| Association for tumor marker: Bombesin |
-Neuroblastoma -Lung cancer -Gastric cancer |
| Association for tumor marker: TRAP |
-Tartrate-resistance acid phosphatase -Found in hairy cell leukemia |
| What type of cell is found in hairy cell leukemia? |
B-cells |
| Association for tumor marker: CA-19-9 |
Pancreatic adenocarcinoma |
| Tumor marker for: Prostatic carcinoma |
-PSA -Prostatic acid phosphatase |
| Tumor marker for: Colorectal cancer |
CEA - Carcinoembryonic antigen -Produced by 70% of colorectal cancers |
| Tumor marker for: Pancreatic cancer |
CEA - Carcinoembryonic antigen -Produced by 70% of pancreatic cancers CA-19-9 -Produced in pancreatic adenocarcinoma |
| Tumor marker for: Gastric carcinoma |
-CEA - Carcinoembryonic antigen -Bombesin |
| Tumor marker for: Breast carcinoma |
CEA - Carcinoembryonic antigen |
| Tumor marker for: Hepatocellular carcinoma |
alpha-fetoprotein |
| Tumor marker for: Nonseminomatous germ cell tumors of the testis |
alpha-fetoprotein |
| Tumor marker for: Hydatidiform moles |
beta-hCG |
| Tumor marker for: Choriocarcinoma |
beta-hCG |
| Tumor marker for: Gestational Trophoblastic tumors |
beta-hCG |
| Tumor marker for: Malignant ovarian epithelial tumors |
CA-125 |
| Tumor marker for: Melanoma |
S-100 |
| Tumor marker for: Neural tumors |
General: S-100 Neuroblastoma: Bombesin |
| Tumor marker for: Astrocytomas |
S-100 |
| Tumor marker for: Metastases to bone |
Alkaline phosphatase |
| Tumor marker for: Obstructive biliary disease |
Alkaline phosphatase |
| Tumor marker for: Paget's disease of bone |
Alkaline phosphatase |
| Tumor marker for: Neuroblastoma |
Bombesin |
| Tumor marker for: Lung cancer |
Bombesin |
| Tumor marker for: Hairy cell leukemia |
TRAP (Tartrate-resistant acid phosphatase) |
| Tumor marker for: Pancreatic adenocarcinoma |
CA-19-9 |
| Cancer associated with: HTLV-1 |
HTLV=Human T-Lymphotropic Virus Adult T-cell leukemia |
| Cancer associated with: HBV |
Hepatocellular carcinoma |
| Cancer associated with: HCV |
Hepatocellular carcinoma |
| Cancer associated with: EBV |
-Burkitt's lymphoma -Nasopharyngeal carcinoma |
| Cancer associated with: HPV |
-Cervical carcinoma (with HPV 16,18) -Penile/anal carcinoma |
| Cancer associated with: HHV-8 |
HHV-8 = Kaposi's sarcoma-associated herpes virus -Kaposi's sarcoma -body cavity fluid B-cell lymphoma |
| Oncogenic virus associated with: Adult T-cell leukemia |
HTLV-1 (HTLV=Human T-Lymphotropic Virus) |
| Oncogenic virus associated with: Hepatocellular carcinoma |
-HBV -HCV |
| Oncogenic virus associated with: Burkitt's lymphoma |
EBV |
| Oncogenic virus associated with: Nasopharyngeal carcinoma |
EBV |
| Oncogenic virus associated with: Cervical carcinoma |
HPV 16 and 18 |
| Oncogenic virus associated with: Penile carcinoma |
HPV |
| Oncogenic virus associated with: Anal carcinoma |
HPV |
| Oncogenic virus associated with: Kaposi's sarcoma |
HHV-8 (aka Kaposi's sarcoma-associated herpesvirus) |
| Oncogenic virus associated with: body cavity fluid B-cell lymphoma |
HHV-8 (Human Herpesvirus 8) |
| Organ affected by: Aflatoxins |
Liver (hepatocellular carcinoma) |
| Organ affected by: Vinyl chloride |
Liver (angiosarcoma) |
| Organ affected by and effects of: CCl4 |
Liver -centrilobular necrosis -fatty change |
| Organ affected by: Nitrosamines |
-Esophagus -Stomach |
| Organ affected by: Cigarette smoke |
-Larynx -Lung |
| Organ affected by: Asbestos |
Lung -Mesothelioma -Bronchogenic carcinoma |
| Organ affected by: Arsenic |
Skin (squamous cell carcinoma) |
| Organ affected by: Naphthalene (aniline) dyes |
Bladder (transitional cell carcinoma) |
| Organ affected by: Alkylating agents |
Blood (leukemia) |
Ch.18 LTI-MA 509
