| Flap 1 |
Flap 2 |
| What drugs cause Cardiovascular Atropine-like side effects |
Tricyclics |
| What drugs cause Cardiac toxicity |
Doxorubicin (Adriamycin), daunorubicin |
| What drugs cause Coronary vasospasm |
Cocaine |
| What drugs cause Cutaneous flushing |
Niacin, Ca2+ channel blockers, adenosine, vancomycin |
| What drugs cause Torsades des pointes |
Class III (sotalol), class IA (quinidine), cisapride |
| What drugs cause Agranulocytosis |
Clozapine, carbamazepine, colchicine |
| What drugs cause Aplastic anemi |
Chloramphenicol, benzene, NSAIDs |
| What drugs cause Gray baby syndrome |
Chloramphenicol |
| What drugs cause Hemolysis in G6PD-deficient patients |
IS PAIN isoniazid (INH), Sulfonamides, primaquine, aspirin, ibuprofen, nitrofurantoin |
| What drugs cause Thrombotic complications |
OCPs (e.g., estrogens and progestins) |
| What drugs cause Cough |
ACE inhibitors |
| What drugs cause Pulmonary fibrosis |
Bleomycin, amiodarone, busulfan |
| What drugs cause Acute cholestatic ;hepatitis |
Macrolides |
| What drugs cause Focal to massive ;hepatic necrosis |
Halothane, valproic acid, acetaminophen, Amanita phalloides |
| What drugs cause Hepatitis |
INH |
| What drugs cause Pseudomembranous ;colitis |
Clindamycin, ampicillin |
| What drugs cause Gynecomastia |
(Some Drugs Create Awesome, Excellent Knockers) Spironolactone, Digitalis, Cimetidine, Alcohol chronicuse, Estrogens, Ketoconazole |
| What drugs cause Hot flashes |
Tamoxifen |
| What drugs cause Gingival hyperplasia |
Phenytoin |
| What drugs cause Osteoporosis |
Corticosteroids, heparin |
| What drugs cause Photosensitivity |
(SAT for a photo) Sulfonamides, Amiodarone, Tetracycline |
| What drugs cause SLE-like syndrome |
(it’s not HIPP to have lupus) |
| What drugs cause Tendonitis, tendon rupture, and cartilage damage (kids) |
Fluoroquinolones |
| What drugs cause Fanconi’s syndrome |
Expired tetracycline |
| What drugs cause Interstitial nephritis |
Methicillin |
| What drugs cause Hemorrhagic cystitis |
Cyclophosphamide, ifosfamide |
| What drugs cause Cinchonism |
Quinidine, quinine |
| What drugs cause Diabetes insipidus |
Lithium, demeclocycline |
| What drugs cause Tardive dyskinesia |
Antipsychotics |
| What drugs cause Disulfiram-like reaction |
Metronidazole, certain cephalosporins, procarbazine, sulfonylureas |
| What drugs cause Nephrotoxicity & neurotoxicity |
Polymyxins |
| What drugs cause Nephrotoxicity & ototoxicity |
Aminoglycosides, loop diuretics, cisplatin |
| P-450 Inducers |
"Queen Barb takes Phenphen ;and Refuses Greasy Carved Steak" Quinidine (can inhibit too), Barbiturates, Phenytoin, Rifampin, Griseofulvin, Carbamazepine, St. John’s wort |
| P-450 Inhibitors |
Inhibitors Stop CyberKids from Eating Grapefruit. Isoniazid; Sulfonamides; Cimetidine; Ketoconazole; Erythromycin; Grapefruit juice |
| Iron Poisioning Mech |
Cell death due to peroxidation of membrane lipids |
| Iron Poisioning Symps |
acute gastric bleeding chronic metabolic acidosis, scarring (leading to GI obstruction) |
| Inhibited by Disulfiram |
Acetaldehyde dehydrogenase |
| Competitive substrates for Alcohol dehydrogenase |
Ethylene glycol, Methanol, Ethanol |
| Ethylene glycol toxicity |
Acidosis, nephrotoxicity |
| Methanol toxicity |
Severe acidosis, retinal damage |
| Ethanol toxicity |
Nausea, vomiting, headache, hypotension |
| The toxicity of which alcoholic compound causes Acidosis, nephrotoxicity |
Ethylene glycol |
| The toxicity of which alcoholic compound causes Severe acidosis, retinal damage |
Methanol |
| The toxicity of which alcoholic compound causes Nausea, vomiting, headache, hypotension |
Ethanol |
| Too much Ethylene glycol can cause what compound to build up? |
Build up of Oxalic acid |
| Too much Methanol can cause what compound to build up? |
Build up of Formaldehyde;and formic acid |
| Too much EtOH can cause what compound to build up? |
Build up of Acetaldehyde |
| If you have a buildup of Oxalic acid, what type of alcohol toxicity is it? |
Ethylene glycol |
| If you have a buildup of formaldehyde, what type of alcohol toxicity is it? |
Methanol |
| If you have a buildup of acetaldehyde, what type of alcohol toxicity is it? |
Ethanol |
| Drugs that cause problems in patients with sulfa allergies |
Celecoxib, furosemide, thiazides, TMPSMX, sulfonyureas, sufasalazine |
| Herbal agents Clinical uses and Toxicities Echinacea |
Common cold; no major toxicities |
| Herbal agents Clinical uses and Toxicities Ephedra |
Same as ephedrine; CNS and cardiovascular stimulation; arrhythmias, stroke, and seizures at high doses |
| Herbal agents Clinical uses and Toxicities Feverfew |
Used for migraine. Adv: mouth ulcers, antiplatelet actions |
| Herbal agents Clinical uses and Toxicities Ginkgo |
Used for Intermittent claudication. Adv: anxiety, insomnia, antiplatelet actions |
| Herbal agents Clinical uses and Toxicities Kava |
Used for Chronic anxiety. Adv: sedation, ataxia, hepatotoxicity, phototoxicity, dermatotoxicity |
| Herbal agents Clinical uses and Toxicities Milk thistle |
Used for Viral hepatitis. Adv: Loose stools |
| Herbal agents Clinical uses and Toxicities Saw palmetto |
Used for Benign prostatic hyperplasia. Adv: ↓ libido, hypertension |
| Herbal agents Clinical uses and Toxicities St. John’s wort |
Used for Mild to moderate depression. Adv: phototoxicity; serotonin syndrome;with SSRIs; induces P450 system |
| Herbal agents Clinical uses and Toxicities Dehydroepiandrosterone |
Used for Symptomatic improvement in females with SLE or AIDS Androgenization (premenopausal women), estrogenic effects (postmenopausal), feminization (young men) |
| Herbal agents Clinical uses and Toxicities Melatonin |
Used for Jet lag and insomnia. Adv: Sedation, suppresses midcycle LH, hypoprolactinemia |
