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pharm 46
male and female hormones
| Question | Answer |
|---|---|
| Secondary sex characteristics | facial hair, body fat distribution, muscle development |
| What are drugs that inhibit the conversion of testosterone into potent androgen 5-alpha (a)-dihydrotestosterone (DHT) | Androgen Hormone Inhibitors |
| Androgen therapy is used as replacement therapy for | testosterone deficiency, hypogonadism, delayed puberty, postmenopausal metastatic breast carcinoma, premenopausal hormone-dependent metastatic breast carcinoma |
| Androgen: Adverse Reactions in Men | impotence, male pattern baldness |
| Androgen: Adverse Reactions in Women | Amenorrhea; virilization produces male pattern baldness, enlargement of clitoris, acne, deepening of the voice, facial hair growth |
| Anabolic Steroids: Adverse Reaction in Women | fluid and electrolyte imbalances, acne, jaundice, “ ’roid rage”, severe depression, inability to concentrate |
| Saw palmetto | used to relieve the symptoms of BPH, may delay the need for prostate surgery |
| Saw palmetto actions | reduces urinary frequency, increases the flow of urine, and decreases the incidence of nocturia |
| Saw palmetto dosage | 160mg twice daily of standardized extract; one 585-mg capsule or tablet up to three times daily; 20-30 drops up to four times a day (tincture, 1:2 liquid extract) |
| Saw palmetto considerations | not recommended to take as a tea because the active constituents are not water soluble |
| How soon can improvement be seen with Saw palmetto? | 1-3 months; recommended to be taken for 6 months |
| Male hormone preadministration assessment | weight |
| Anabolic steroids preadministration assessment | weight, blood test results for liver function and lipids |
| Ongoing assessment for androgen or anabolic steroid | weigh daily, notify PHCP if significant increase or decrease in weight |
| Androgen hormone inhibitors and meals | can be given without regard to meals |
| Androgen or anabolic steroid implementation of excess fluid volume | monitor fluid and electrolyte disturbances, sodium and water retention, weight; report signs and symptoms of puffy eyelids, dependent edema |
| Anabolic steroids teaching | take drug with food or meals, keep PHCP or clinic visits |
| Androgen hormone inhibitor teaching | pregnant women or those who may become pregnant should not handle these medications (Proscar, Avodart) |
| Action of estrogens include | fluid retention, protein anabolism, thinning of the cervical mucus |
| Estrogens contribute to | conservation of calcium and phosphorus |
| Estrogens stimulate contraction of | fallopian tubes |
| Estrogen is safer in use with women who have | high triglycerides, HTN, diabetes, and migraines |
| Progestins: Uses | treatment of amenorrhea, endometriosis, functional uterine bleeding, and as oral contraceptives |
| Estrogen dermatologic adverse reaction | chloasma and melasma |
| Estrogen warning | hepatic adenoma |
| Estrogen signs of Excess | nausea, bloating, cervical mucorrhea, polyposis, hypertension, migraine headache, breast fullness or tenderness, edema |
| Estrogen signs of deficiency | early or midcycle breakthrough bleeding, increased spotting, hypomenorrhea melasma (discoloration of the skin) |
| Progestin signs of Excess | increased appetite, weight gain, tiredness, fatigue, hypomenorrhea, acne, oily scalp, hair loss, hirsutism (excessive growth of hair), depression, monilial vaginitis, breast regression |
| Progestin signs of deficiency | late breakthrough bleeding, amenorrhea, hypermenorrhea |
| Female hormone ongoing assessment | obtain blood pressure, pulse, respiratory rate and weight, question patient regarding any adverse drug effects, as well as, the result of drug therapy therapeutic effects |
| Monitoring and managing patient’s needs with excess fluid volume | may need to decrease dietary intake of sodium; occasional bloating with meals can be treated with limiting fluids at meals |
| Monitoring and managing patient’s needs with imbalanced nutrition | encourage diet with adequate amounts of protein and carbohydrates, low in fats |
| Monitoring and managing patient’s needs with ineffective tissue perfusion | monitor patient for signs of thrombolic effects; increased risk with patients who have venous insufficiency and who smoke; elevate legs, ambulation |
Created by:
laotracuata
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