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NURS 572A-12

Neuropharmacology principles

QuestionAnswer
neuropharmacology definition study of drugs that alter processes controlled by nervous system
2 basic processes that neuron influences post-syn cell *axonal conduction *synaptic transmission
Most npharm drugs act bwo alterning synaptic transmission
Axonal conduction affects ALL nerves to which it has access, non-selective effects
Example of axonal drug local anesthetics
Why is synaptic transmission so selective Different ntrans combined with different receptors
Impact of drug on neuronally regulated process is dependent upon the ability of the drug to directly/indirectly influence receptor activity on target
5 steps of synaptic transmission *transmitter synthesis *transmitter storage *transmitter release *receptor binding *termination of transmission
Effects of receptor binding undergo reversible binding --> cascade of events alter behavior in postsyn
Mechanisms of termination of transmission *reuptake *enzymatic degradation *diffusion away from gap (slow, insignificant)
Enzyme location for reuptake method ntran pumped back into cell, then degraded by enzyme or recycled/repackaged
enzyme location for ntran degradation method synaptic gap
effect of drug on ntran synthesis Increase/decrease/superT (enhanced ntran)
Effect of drug on ntran storage reduced
Effect of drug on ntran release promotes/inhibits
effect of drug on receptor binding -3 *direct receptor activation *enhanced response to ntran *blockade of ntran binding
effect of drug on ntran termination *block ntran reuptake *inhibit enzymatic degradation
Created by: lorrelaws
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