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INH
NCLEX Review
Question | Answer |
---|---|
INH | Isoniazid |
Class | Antituberculars |
Indication | First line therapy of active tuberculosis |
Action | Inhibits myobacterial cell wall synthesis and interferes with metabolism |
Caution | With history of liver damage, renal impairment, malnourished patients |
Adverse reactions | psychosis, seizures, Visual distrubances, Drug induced hepatitis, nausea, vomiting, rashes, blood dyscrasias, peripheral neuropathy |
Labs | hepatic function should be evaluated prior to and monthly througout therapy, |
Toxicity and overdose | treatment with pyridoxine (vit B) |
PO | May be given with food or antacids if GI irritation occurs |
pyridoxine | may be used concurrently to prevent neuropathy |