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P&P 2010 infl k

P&P 2010 inflmation k

QuestionAnswer
Anything that causes tissue/cell damage, Injury (Direct damage),Chemicals,Physical agents – heat, cold,Foreign bodies, Ischemia, Infection are causes of ? inflammation
One component of the second line of defense.is inflammation
Neutralize the cause,Keep damage localized,Establish an environment suitable for repair and healing are objectives of ? inflammation
A sequential response is called inflammation
Suffix – itis is an inflammation
a cellular bag of granules located in loose connective tissues close to b.v.’s is a Mast cell degranulation
Basophils in blood serve the ? same function
the release of histamine is called Degranulation
what stimulates the release of chemical mediators & cytokines
Kinins, Complement, Prostaglandins are chemical mediators
what causes Vasodilation, increased vascular permeability, bronchoconstriction, vomiting, stimulates nerve ending for pain & itch histamine
what is Stored in body fluids (inactive),Activated by histamine & dying WBC’s, Kininse eg Bradykinin
increased & prolong vasodilation, and increased vascular permeability are started by histamine kept going by kininse
total of ? Complments 20
Complement Cascade is Synthesized by the liver
Tissue injury, and Antigen-antibody reaction initiates cascade of complements
complements that change surface tension of foreign cells so phagocytes can adhere (C3b) are called Opsonization
Chemical mediators found in all body tissues that act locally where they are released are called Prostaglandins
Vasodilation,increase vascular permeability, Control platelet function, increase sensitivity to pain are actions of inflammation
? are Chemical messengers, and Proteins secreted by cells Cytokines
Monokines stimulate monocytes,Lymphokines stimulate lymphocytes- Immune response in ? inflammation
Redness, Swelling, Heat, Pain, Possible Loss of Function are sings of ? inflammation
WBC’s are attracted to the site by bacteria, tissue debris & cytokines during ? Chemotaxis
when WBC’s “line-up” (Pavementing)its called Margination
when WBC are ‘Squeezing through’ to the tissues its called Diapedesis
1st to arrive at the site of injury are the (within 90 minutes) neutrophils
2nd –to arrive at sight of in injury monocytes
macrophages are what type of leukocyte big eaters
also release ? which causes a fever Interleukin 1
Fever, Leukocytosis, are signs of ? systemic inflammation
? digests dead cells macrophages
? eats the forgein cells phagocytes
monocytes make ? macrophages
Created by: kfroel4
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