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AntilipemicDrugs
VascDrugs
Question | Answer |
---|---|
HMG CoA Reductase Inhibitors (HMGs or statins) | Most potent LDL reducers - lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), atrovastatin (Lipitor), fluvastatin (Lescol)S/E Mild transient GI disturbances, Rash, HA, Myopathy leading to skeletal muscle b/d elv. liver enzymes |
Bile Acid Sequestrants | cholestyramine (Questran)*colestipol hydrochloride (Colestid), coleseelam (tablet form), AKA bile acid binding resins & ion exchange resins S/E Constipation, Heartburn, Nausea, Belching bloating - decrease over time |
Niacin (Nicotinic Acid) | Vitamin B3 requires much higher dose than reg. vit. thought to increase activity of lipase (b/d lipids) S/E: Flushing - take NSAID 30 min. before, Pruritis, GI distress |
Fibric Acid Derivatives (AKA fibrates) | gemfibrozil (Lopid), fenofibrate (Tricor)b/d lipase faster & more effective, decreases triglyceride levels, increses hdl by as much as 25% S/E: Abdominal discomfort, diarrea, nausea, blurred vision, HA, gallstone risk, prolonged prothrombin time, liver |
Cholesterol Absorption Inhibitor | ezetimibe (Zetia), inhibits absorption of cholesterol from the small intestines, reduces total cholesterol, LDL, triglyceride levels, increases HDL levels, Works well when taken with a statin drug |