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N126-U3-I. MI/CHF #5
Dobrisky-Cardiac Module: Cardiac enzymes
| Question | Answer |
|---|---|
| When will CPK show signs of an MI | 3-6 hours |
| When will LDH show signs of an MI | 8-12 hours |
| When will SGOT (AST) show signs of an MI | 6-10 hours |
| When will Serum troponin I show signs of an MI | 3 hours to 7 days |
| When will serum troponin T show signs of an MI | 3.5 hours to 12-14 days. |
| CPK stands for | Creatinine phosphokinase |
| CPK is predominantly found where? | heart muscle, skeletal muscle and brain |
| When does CPK rise? | when injury occurs in these cells. |
| CPK peaks in | 12-18 hours |
| CPK returns to normal within | 3-4 days |
| What enzyme is specific to cardiac tissue? | CPK-MB |
| Which is the first cardiac enzyme to be elevated with MI? | CPK-MB |
| SGOT stands for | serum glutamic-oxalocetic transaminase or aspartate aminotransferase |
| SGOT (AST) is found in ____ concentrations in heart muscle, liver cells, skeletal muscle cells | high |
| SGOT (AST) is found in ______ concentrations in the kidney and pancreas | lower |
| Which enzyme is useful in the diagnosis and determination of timing in a recent MI? | SGOT (AST) |
| SGOT/AST levels being to rise in | 6-10 hours |
| AST/SGOT levels peak in | 24-36 hours |
| AST/SGOT levels return to normal in | 4-7 days |
| LDH stands for | lactic dehydrogenase |
| LDH is found in the | heart, liver, kidneys, skeletal muscle, brain, red blood cells and lungs |
| serum LDH levels begin to rise within | 12 hours |
| LDH levels peak around | 48 hours |
| LDH levels return to normal within | 10-14 days |
| Why isn't LDH considered a specific indicator of myocardial infarction? | it is widely distributed throughout the body |
| LDH is fractionated into | 5 isoenzymes |
| LDH-1 comes maily from | heart and blod vessels |
| LDH-__ is a more sensitive indicator of myocardial infarction than the total LDH level | 1 |
| When LDH-1 activity is greater than LDH-2 activity it is called ________ | flipped LDH |
| Flipped LDH is a strong indicator of | MI |
| In an acute MI, the flipped LDH ratio usually appears in | 12-24 hours and is usually present within 48 hours in 80% of patients |
| When LDH-2 is greater than LDH-1 it is considered evidence ________ myocardial infarction. | against |
| What is the normal ratio of LDH 1 & 2? | LDH-2 is normally greater than LDH-1 |
| What serum enzyme testing time frame will give the most comprehensive picture of a myocardial event? | 3-4 days |
| Serum enzyme testing over 3-4 days will also determine what? | if ongoing damage is occuring from additional infarction |
Created by:
Lori Dobrisky
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