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TT2 THIAZIDE DI

TT2 NHCC THIAZIDE DIURETICS

QuestionAnswer
What are some examples of THIAZIDE DIURETICS? Metolazone, Hydrochlorothiazide, Bendroflumethiazide, Benzthiazide, Chlorothiazide, Polythiazide, Trichlormethiazide
What is the action? 1. Increase excretion of sodium and water by inhibiting sodium reabsorption in the distal tubule
What are the uses? 1. Treatment of hypertension, 2. Treatment of edema due to renal dysfunction, 3. Adjunct in treating edema due to CHF, hepatic cirrhosis, corticosteroid/estrogen therapy
What are the Major side effects & adverse reactions of the CNS? dizziness, vertigo, paresthesia, HA
What are the Major side effects & adverse reactions of the EENT? blurred vision
What are the Major side effects & adverse reactions of the GI? anorexia, N/V and diarrhea, jaundice
What are the Hem. major side effects & adverse reactions? agranulocytosis, aplastic anemia, leucopenia, thrombocytopenia
What are the Major side effects & adverse reactions of the Int.? urticaria, photosensitivity
What are the Major side effects & adverse reactions of the met? hypokalemia, glycosuria, hyperglycemia
What are the Major side effects & adverse reactions of the muscles? fatigue, leg cramps
What are the Major side effects & adverse reactions of respiratory? respiratory distress
What are the CONTRAINDICATIONS? 1. Known drug allergy,2. Hepatic coma , 3. Anuria, 4. Severe renal failure
What are the PHARMACOKINETICS? metabolized in the liver, excreted in the kidney
What are the interactions? 1. Corticosteroids – additive effect 2. Diazoxide – additive effect 3. Digoxin – hypokalemia 4. Lithium - ↑ Lithium toxicity 5. NSAIDS - ↓ Diuretic activity
Created by: 2007Nurse
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