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TT2Antianginal
TT2 NHCC Antianginal – Oral Nitrates
Question | Answer |
---|---|
What is the action of antiangials? | 1. Dilate blood vessels – potent effect on coronary arteries . 2. Metabolized in liver – High first pass effect |
What are the uses for Antianginals? | 1. ↑ blood flow to ischemic myocardium, 2. ↓ myocardial O2 demand, 3. Nitrates – dilate coronary arteries & cause systemic vasodilatation (↓ preload), 4. Acute relief of angina pectoris, 5. Hypertensive crisis |
What are the major side effects? | 1. Headache, 2. Tachycardia, 3. Postural hypotension, 4. Methemoglobinemia (rare), 5. Tolerance |
What are the CONTRAINDICATIONS? | 1. Drug Allergy, 2. severe anemia, 3. closed angle glaucoma, 4. severe head injury, 6. Caution: PG/lactating, postural hypotension |
What are the PHARMACOKINETICS? | metabolized by the liver and excreted by the kidneys. |
What are the interactions? | 1. Additive hypotension with alcohol, beta blockers, CCBs (Ca channel blockers), phenothiazines, sildenafil (viagra) – |
What do CCB's do? | CCB’s dilate coronary arteries (some slow heart rate. |
What do cold temperatures and tobacco do to antiangials? | May reduce the effect |