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83 — ATI Ch. 8
Depressive Disorders
Question | Answer |
---|---|
What type of drug is Fluoxetine? | SSRI |
Therapeutic uses of Fluoxetine? | depression, OCD, bulimia, PMS, panic disorders, PTSD, anxiety disorders, bipolar |
AE of Fluoxetine | CNS stimulation, weight loss, serotonin syndrome. withdrawal, hyponatremia, rash, sleepiness, faintness, lightheadedness, GI bleeding, bruxism |
When does serotonin syndrome begin? | 2-72 hr after treatment |
CI for Fluoxetine? | pregnancy, MAOI/TCA usage, liver/renal dysfunction, CV disease, seizures, diabetes, ulcers, GI bleed hx |
Ixns with Fluoxetine? | TCAs, MAOIs, St. John's wort, warfarin, trcyclics, NSAIDs, anticoagulants |
What type of drug is Venlafaxine? | SNERI |
Example of SNERI? | Venlafaxine |
MOA of Venlafaxine? | block reuptake of both NE & serotonin |
Tx for Venlafaxine? | depression, panic disorder, social anxiety, GAD, pain due to chronic illness |
AE of Venlafaxine? | nausea, anorexia, headache, insomnia, anxiety, HTN, TCA, dizziness, blurry vision, withdrawal, adolescent suicide, impotence, serotonin syndrome |
CI for Venlafaxine? | pregnancy, breastfeeding, SSRI/MAOI/TCA usage, elderly, bipolar, seizures, lung/heart disease |
Ixns with Venlafaxine? | MAOIs, NSAIDs, alcohol, CNS depressants, Kava, Valerian, St. John's wort |
What type of drug is Bupropion? | Atypical antidepressant |
Example of an atypical antidepressant? | Bupropion |
MOA of Bupropion? | blocks reuptake of NE & dopamine |
Tx of Bupropion? | depression, SSRI-related impotence, smoking cessation, seasonal depression, ADD |
AE of Bupropion? | headache, dry mouth, N/V, constipation, tachycardia, HTN, restlessness, insomnia, anorexia, seizures |
CI for Bupropion? | MAOI usage, seizures, eating disorders |
Ixn for Bupropion? | MAOI |
What type of drug is Vilazodone? | atypical antidepressant |
MOA of Vilazodone? | serotonin blockers & agonist |
What food to avoid when taking Vilazodone? | grapefruit juice |
How to increase absorption of Vilazodone? | take with food |
MOA of Mirtazapine? | increase release of serotonin & NE |
MOA of Nefazodone? | selective inhibition of serotonin & NE reuptake |
MOA of Trazodone ER? | selective serotonin blockade |
What's special about Trazodone ER? | usually used with another antidepressant |
Important AE of Trazodone ER? | priapism |
What food to avoid when taking Trazodone ER? | grapefruit juice |
What type of drug is Amitriptyline? | tricyclic antidepressant |
MOA of Amitriptyline? | block reuptake of NE & serotonin |
AE of Amitriptyline? | orthostatic HOTN, anticholinergic effects, sedation, toxicity, seizure, sweating |
CI for Amitriptyline? | pregnancy, breastfeeding, any chronic disease of any body system, prostatic hyperplasia, hyperthyroidism, suicide |
What type of drug is Phenelzine? | MAOI |
MOA of Phenelzine? | increase amounts of NE, dopamine, serotonin, tyramine |
AE of Phenelzine? | CNS stimulation, Orthostatic HOTN, HTN, local rash |
CI for Phenelzine? | heart problems |