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Inflamm-AO

Patho-9/3 AO

QuestionAnswer
Example of physical barrier epithelial cells (skin-mucous membranes)
Example of biochemical barrier normal bacteria flora
Classic Symptoms of inflammation redness, swelling, pain, heat, loss of function
Steps of Inflammatory Response 1. injury 2. Cells release chemical mediators (histamines, chemotactic factors, leukotrienes, prostaglandins) 3. Vasodialation-inc blood flow 4. Leukocytes move to the site of injury 5. Phagocytosis-removal of bacterial prod
Local manifestations of acute inflammation swelling, pain, heat, redness
Systemic manifestations of acute inflammation fever, inc leukocytes, inc levels in circulating plasma protien
Consequence Macrophage infiltration pus/granuloma
Differentiation of macrophage into lg epithelioid cells form center of granuloma and can become calcified
Consequence Tissue repair scar tissue
What is an antigen? Where are antigens found? initiates an immune response. B&T cells
What role do B and T cells play? T-kill target, reg immune response, helper to prevent cancer and infection B-produce antibodies
IgG most common. Production activity against infection. Crosses placenta
IgA secretatory cholestrum, tears, etc
IgM First and largest antibody produced bound to B lymphocytes.
IgE mediator of many common allergic reactions
Type 1 hypersensitivity response IgE mediate reaction ex:asthma exacerbation
Type II hypersensitivity response tissue specific reaction ex: blood transfusion reaction
Type III hypersensitivity response immune complex mediated reaction ex. systemic lupus erythematosus
Type IV hypersensitivity response cell-mediated reaction ex: organ tissue rejection
Primary (congenital) immune deficiency genetic. Ex: DiGeorge syndrome
Secondary (acquired) immune deficency acquired complication of physiological AIDS
Which cell types associated with the inflammatory response participate in phagocytosis? Neutrophils Macrophages Monocytes
Created by: cristinab1986
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